Okuno Clinic
Tokyo, Tokyo, Japan
Yuji Okuno, MD PhD, Okuno Clinic.
I started my career as an interventional radiologist and from that experience through it, I had a clinical question "Why can a blood vessel with disturbed structure be formed in cancer or inflammation?" And to solve it, I focused on pathological angiogenesis when I was engaged in basic research of vascular science that I did during my graduated student researcher. From this work we found genes involved in the pathogenesis of pathological angiogenesis and I reported the results of the study to Nature Medicine in 2012 as a first author1. Based on these experiences, from the viewpoint that reduction of abnormal diseased blood vessels leads to improvement of chronic inflammatory diseases, I have developed a treatment using embolization technique applying to chronic musculoskeletal disorders, such as knee osteoarthritis2 and frozen shoulder3 and reported its safety and usefulness in the world for the first time by conducting clinical researches. At present, this procedure is beginning to be confirmed for safety and usefulness in third parties in other countries.
1. Okuno, Y., Nakamura-shizu, A., Otsu, K., Suda, T. & Kubota, Y. Pathological neoangiogenesisdepends on oxidative stress regulation by ATM. Nature Med 2012
2. Okuno Y, Korchi AM, Shinjo T, Kato S. Transcatheter arterial embolization as a treatment for medial knee pain in patients with mild to moderate osteoarthritis. Cardiovasc Intervent Radiol. 2014 Jul 4.
3. Okuno Y, Oguro S, Iwamoto W, Miyamoto T, Ikegami H, Matsumura N. Short-term results of transcatheter arterial embolization for abnormal neovessels in patients with adhesive capsulitis: a pilot study. J Shoulder Elbow Surg. 2014 Mar 4
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