(961.4) Safety Profile of Short-Term Creatine Nitrate and Caffeine Co-Ingested in Resistance Trained Participants

Poster Board Number: E630

Gina Mabrey (Jacksonville State University), Majid Koozehchian (Jacksonville State University), Andrew Newton (Jacksonville State University), Alireza Naderi (Qatar University), Monoem Haddad (Islamic Azad University, Boroujerd Branch), Scott Forbes (Brandon University)

Caffeine and creatine nitrate are two commonly used ergogenic aids purported to augment resistance and anaerobic performance; however, the safety profile of these supplements co-ingested is unknown. The purpose was to examine the effects of caffeine and creatine nitrate alone and co-ingested on several biochemical blood markers (creatine kinase, lactate dehydrogenase, cholesterol, alanine aminotransferase, aspartate transaminase, alkaline phosphatase, white blood cells, lymphocytes, red blood cells, hematocrit, and hemoglobin), resting heart rate and blood pressure, and self-reported side effects.

Methods: In a double-blind, randomized, placebo-controlled cross over study, 12 resistance-trained participants (22±1 y; 180.0±9.5 cm; 85.9±15.1 kg) completed 4 conditions in random order: creatine nitrate (CN: 5 g/day + 0.675 g/day of maltodextrin), caffeine (CAF: 400 mg/day + 5 g/day of maltodextrin), CN+CAF (5 g/day of creatine nitrate + 400 mg/day of caffeine), and placebo (PL: 5.4 g/day of maltodextrin). Supplements were ingested for 7 days with a 7-day washout period between conditions. Before and after supplementation, participants provided a blood sample collected from the antecubital vein and measured resting heart rate and blood pressure. A standardized side effect questionnaire was also completed following each condition. Data were analyzed using a two-way (within-within) analysis of variance (p≤0.05) with a Tukey’s post hoc when appropriate. For side effects, a chi-squared non-parametric test was used.

Results: There was no interaction or main effects for all blood parameters (pgt;0.05). Resting heart rate and blood pressure were also not different between conditions or over time (pgt;0.05). Lastly, there were no significant differences between conditions for any side effects on the side effect questionnaire (pgt;0.05).

Conclusion: Short-term CAF, CN, and CAF+CN co-ingestion appears safe for healthy young resistance-trained participants.