(512.3) Genesis of Antibiotic Resistance (AR) LXXXVI: Turbulence Modeling(TM) of Hemodynamics in Simplified Severe Sepsis Protocol-2 (SSSP-2)-NCT01663701: Mechanism(s) of ISP Afloat Transient APG Thrust VKVS free shear flow augmented cerebral vessel collapse, GCS3, & IHM

Poster Board Number: A366

Hector Montoya (City of Eagle Pass Water Works), Jorge Flores (City of Eagle Pass Water Works), Subburaj Kannan (Southwest Texas Junior College)

Based on the theoretical inferences from the CFD pertaining to VKVS/vortices/shedding frequency/vortex-induced vibration/ hysteresis effect, Shed Vortex, and Karman/symmetric vortex shedding, Courtesy: Flow-3D HydroÒ, COMSOL Multiphysics®, © 2021, NASA-U.S: https://earthobservatory.nasa.gov/images/85989/canary-islands-kick-up-von-karman-vortices , Harvard Natural Sciences Lecture Demonstrations https://sciencedemonstrations.fas.harv... https://www.youtube.com/watch?v=_Hbbkd2d3H8 , Vortex shedding; https://www.youtube.com/watch?v=ahohd8ceGR4,  and hemodynamic data from NCT01663701, here we present a plausible physiological basis for the effect of fluid bolus augmented VKVS, eliciting ISP, thrust skewed viscosity/velocity profile rupturing and cause the cerebral hemorrhage, that leads to precipitous ihm in the usual care cohort of SSSP-2 (PMID: 28973227). Hypothesis: Fluid bolus augmented VKVS augment incompressible free shear flows in cerebral arteries ensue decomposition of glycocalyx/endothelium as a function of time, viscosity and velocity profiles. Geometry: RBC, WBC, platelets, p47; p53; Table 2.1 p63, Table 2.2, p64; Fig 2.15 p 78; ISBN:9780128024089. Governing Equation, Derivation and Prospects (Physiological Connotation): Subsequent to fluid bolus induced fluid volume expansion is a function altered viscosity (hematocrit) dependent velocity profile as a function of time augment five different free shear flow: a. far wake, downstream of ZoO, b. mixing layer, downstream of ZoO occurring between two parallel streams with different velocity profile, c. plane jet, d. round jet, occur downstream of ZoO, and e. constrained radial jet, occur when two jets of similar velocity profile, (possibly different viscosity) in a turbulent flow; Assumptions based on the hemodynamic data from NCT016637001: I. Aforesaid free shear flow has self-similarity, self-preserving; Velocity component: Equation, 3.22; II. two velocity profiles located downstream at locations x1 and x2 are not same: equation, U (x, y)/uo (x) [or (U-U (x, y)/U0(x) for the wake); III. Boundary layer approximations are not valid for aforesaid free shear flows, IV. molecular transport momentum differs at different location; V: pressure not the same thought vessels, VI: no continuity (equation of motion refer equation 3.23; 3.24; VII: closure coefficient differs for different points in the cerebral/ coronary circulation, applicable governing equations for the eddy-viscosity model, Eq:3.25, p60-61; ISBN-13: 978-1928729082. Taken together, fluid bolus induced fluid volume expansion augment cyclical anaerobic/aerobic milieu conferring altered generation time(G): G=t/n, where time (t) per generation (n = number of generations) for ClPr exacerbating toxic shock expedite irreversible loss of vasculature penultimate ihm in usual care group of NCT01663701.

PD funds by SWTJC and MyCE-HMS, Neuropsychiatry by Subburaj Kannan