(532.1) Acute Low Dose Cannabidiol Treatment Boosts Social Interaction Preference in Male Mice
Sunday, April 3, 2022
10:00 AM – 12:00 PM
Location: Exhibit/Poster Hall A-B - Pennsylvania Convention Center
Poster Board Number: B10
Georgianna Gould (University of Texas Health Science Center at San Antonio), Livia Ferreira (University of Texas Health Science Center at San Antonio), Nikhita Pathapati (University of Texas Health Science Center at San Antonio), Mary Nunn (University of Texas Health Science Center at San Antonio), Susan Greene (University of Texas Health Science Center at San Antonio), Brett Ginsburg (University of Texas Health Science Center at San Antonio), Stephen Schultz (University of Texas Health Science Center at San Antonio)
Presenting Author University of Texas Health Science Center at San Antonio San Antonio, Texas
Cannabidiol (CBD) is a non-addictive psychoactive phytochemical from Cannabis sativa that is increasingly used to manage pain. The potential for CBD to ameliorate some psychiatric disorder symptoms has been suggested, including the social behavior deficits of autism. To test this hypothesis, adult male BTBRT+Itpr3tf/J (BTBR) mice, a model of idiopathic autism, were acutely treated with vehicle or 0.1, 1, or 10 mg/kg CBD. Social interaction preference was assessed 50 min after treatment, followed by social novelty preference at 60 min, marble burying at 75 min and social dominance at 120 min. CBD (10 mg/kg) enhanced BTBR social interaction but not social novelty preference, marble burying or dominance, with serum levels = 29 ± 11 ng/mg at 3 h post-injection. Next, acute 10 mg/kg CBD was compared to vehicle treatment in serotonin transporter (SERT) knockout mice, as SERT deficiency is an autism risk factor, and in C57BL6/J mice. CBD treatment generally enhanced social interaction preference and attenuated social novelty preference, yet neither marble burying nor dominance was affected. These findings show acute treatment with purified CBD can enhance social interaction preference at a relatively low dose. However, the pharmacological target(s) by which this low dose of CBD enhanced sociability remain to be demonstrated. Any use of unregulated CBD products to treat autism symptoms in children is not advisable until product purity and dose are strictly controlled, and acute versus long term treatment effects are better known.
Support or Funding Information
The project described was supported by the National Institutes of Healths National Center for Research Resources and the National Center for Advancing Translational Sciences, through Grant 8UL1TR000149, and contract from the Naval Medical Research Unit San Antonio. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH or Department of Defense.
The project described was supported by the National Institutes of Healths National Center for Research Resources and the National Center for Advancing Translational Sciences,amp;nbsp;through Grantamp;nbsp;8UL1TR000149, and contract from the Naval Medical Research Unit San Antonio. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH or Department of Defense.
In adult male BTBR and SERT knock out mice, acute administration of 10 mg/kg CBD enhanced social interaction preferences otherwise impaired. Pharmacological target(s) of CBD at this dose are unclear.