(627.2) Plasma Concentrations of Trace Elements Selenium and Cobalt During and After Coronary Artery Bypass Grafting Surgery

Poster Board Number: E681

Jia-Yi Zhou (The Institute of Cardiovascular Diseases amp; Department of Cardiovascular Surgery, TEDA International Cardiovascular Hospital, Tianjin University amp; Chinese Academy of Medical Sciences), Hai-Tao Hou (The Institute of Cardiovascular Diseases amp; Department of Cardiovascular Surgery, TEDA International Cardiovascular Hospital, Tianjin University amp; Chinese Academy of Medical Sciences), Shi-Fu Wang (The Institute of Cardiovascular Diseases amp; Department of Cardiovascular Surgery, TEDA International Cardiovascular Hospital, Tianjin University amp; Chinese Academy of Medical Sciences), Qin Yang (The Institute of Cardiovascular Diseases amp; Department of Cardiovascular Surgery, TEDA International Cardiovascular Hospital, Tianjin University amp; Chinese Academy of Medical Sciences), Guo-Wei He (The Institute of Cardiovascular Diseases amp; Department of Cardiovascular Surgery, TEDA International Cardiovascular Hospital, Tianjin University amp; Chinese Academy of Medical Sciences, The Institute of Cardiovascular Diseases amp; Department of Cardiovascular Surgery, TEDA International Cardiovascular Hospital, Tianjin University amp; Chinese Academy of Medical Sciences, The Institute of Cardiovascular Diseases amp; Department of Cardiovascular Surgery, TEDA International Cardiovascular Hospital, Tianjin University amp; Chinese Academy of Medical Sciences)

Objectives: Trace elements selenium (Se) and cobalt (Co) have been known to be essential in the human body and the correlation between Se and cardiac surgery has been suggested. The present study was designed to investigate the plasma concentration of Se and Co during and after coronary artery bypass grafting (CABG) surgery under cardiopulmonary bypass (CPB).

Methods: From December 2019 to January 2020, preoperative plasma samples from isolated first-time CABG patients (N=20; 10 males and 10 females) were prospectively collected at five points: after anesthesia and before CPB (T1), 45 min after CPB started (T2), 90 min after CPB started (T3), postoperative day1 (T4), and day 4 (T5), respectively. The concentration of Se and Co was measured.

Results: The concentration significantly decrease for Se at T2 (105.24 ± 4.08 vs. 68.56 ± 2.42μg/L, P lt; 0.001) and T3 (105.24 ± 4.08 vs. 80.41± 3.40μg/L, P lt; 0.001) and for Co at T4 (0.35 ± 0.19 vs. 0.26 ± 0.13μg/L, P lt; 0.01) and T5 (0.35 ± 0.19 vs. 0.23 ± 0.11μg/L, P lt; 0.001).  There was no operative mortality or major morbidity except that five patients developed atrial fibrillation (AF).

Conclusions: This study for the first time identified the alteration of plasma concentration of Se and Co during and after CABG surgery. The findings may suggest that supplementation of Se before or during CABG and that of Co after CABG may become necessary for patients undergoing CABG.  Further studies are warranted.

lt;igt;Supported by the National Natural Science Foundation of China [82170353 amp;amp; 81870288]; the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences [2020-PT310-007 amp;amp; 2019XK310001]; Tianjin Science and Technology Project [18PTZWHZ00060].lt;/igt;lt;igt; TEDA International Cardiovascular Hospital [2021-ZX-004 amp;amp; TD-2020-010]lt;/igt;