Session: 556 APS Endothelial Cell Biology in Health and Disease Poster Session
(556.1) The effect of novel second generation prebiotics (levan of β-[2,6]-glycosidic linkages) on the cardiovascular system in obesity
Sunday, April 3, 2022
10:15 AM – 12:15 PM
Location: Exhibit/Poster Hall A-B - Pennsylvania Convention Center
Poster Board Number: E93
Amal Sahyoun (University of Tennessee Health Science Center, McGill University), Young-In Kwon (University of Tennessee Health Science Center), Undral Munkhsaikhan (University of Tennessee Health Science Center), Salwa Karboune (McGill Univeristy), Modar Kassan (University of Tennessee Health Science Center)
Presenting Author University of Tennessee Health Science Center, McGill University
Objectives: Bacteria dysbiosis is very well documented in obesity and is known to regulate the cardiovascular system. Recovering the bacteria composition is a key element in improving the cardiovascular function during obesity.
Hypothesis: In this study we investigate the effect of levan, a novel second generation of prebiotic (β-[2,6]-linkages, on the cardiovascular system in obesity.
Methods: Eight-week-old C57/b6 mice were fed with high fat diet (HFD) for 12 weeks in the presence and absence of levan (β-[2,6]-linkages). Treatment was administered by gavage (250 mg/kg) for the last 30 days of HFD feeding. Body weight, blood glucose, body composition and lipid profile were determined. Vascular function and endothelial function markers were studied in aorta and mesenteric resistance arteries (MRA).
Results: Levan (β-[2,6]-linkages) treatment reduced the body weight in obese mice. Blood glucose, % of fat mass, total cholesterol, and LDL levels were significantly reduced and the % of lean mass was significantly increased after Levan (β-[2,6]-linkages) treatment. Aortic and mesenteric arteries vascular response to sodium nitroprusside (SNP) was similar among groups. However, the vascular response to acetylcholine (Ach) was improved in the treated group.
Conclusions: Treatment with Levan (β-[2,6]-linkages) attenuated the increase in body weight in obese mice and restored the lipid profile and the vascular function.
