Breast cancer is the most frequently diagnosed cancer in women and ranks second among causes for cancer-related deaths in women. The heritable component in familial clustering of breast cancer has been estimated to be 73% and the environmental proportion 27%. These high penetrance traits and the identification of the breast cancer-predisposing gene PTEN, warrant further research. In this analysis, we specifically looked at PTEN single nucleotide polymorphisms (SNPs) and their association with breast cancer. Genome-Wide Sequencing data was obtained from the Sequence Read Archive and then analysis pipelines were constructed to map the sequences against chromosome 10 followed by indexing and variant calling. Through our analytical tools, we were able to detect variants in benign breast tissue samples that were absent in breast cancer tissue samples. These findings help support previous studies that link the tumor suppressor activity of PTEN with genetic susceptibility to breast cancer.
