"Attention deficit hyperactivity disorder (ADHD) and glioblastoma multiforme (GBM) are two neurological disorders with high rates of incidence and mortality respectively, both capable of inflicting long-term physiological damage. Although prior research has indicated that brain tumor survivors exhibit increases in susceptibility to ADHD, the underlying genetic components still remain relatively unknown. The primary purpose of this investigation was to identify genetic associations between ADHD and GBM by single-nucleotide polymorphisms (SNPs) of target genes. NCBI’s Gene Expression Omnibus was accessed, and genes of interest were selected by differential gene expression analysis in GBM patients. Sequence data of ADHD and GBM patients were obtained from the Sequence Read Archive (SRA), followed by the construction of analysis pipelines to map the sequences against human chromosome 12, followed by indexing and variant calling. This study highlights 18 variants (including 7 reported SNPs) that contribute to the genetic overlap of ADHD and GBM and may provide a useful tool for precision medicine.
Keywords: SNPs, glioblastoma, ADHD
18 loci on human chromosome 12 that exhibit increased incidence compared to the reference human genome assembly GRCh38, and their associated rs number (if applicable) and gene. Incidence of the 99 total patients analyzed for ADHD and GBM cohorts, on an increasing scale of 0 to 1. Welch’s T-tests were calculated, with p-value < 0.05 across the two disorders.; Incidence rates of the top 7 recorded SNPs across 99 ADHD and GBM patients in chromosome 12 compared to the control group (in orange)."
