(796.16) Inhibition of human ERα-positive breast carcinoma cell by baicalein via cell cycle arrest and apoptosis

Poster Board Number: A167

Lovelyn Epelle (University of Michigan - Flint), Benjamin Woerner (University of Michigan - Flint), Miguel Strawn (University of Michigan - Flint), Nicodemus Monear (University of Michigan - Flint), Tristan Nelson (University of Michigan - Flint), Besa Xhabija (University of Michigan - Flint)

Baicalein is a naturally occurring flavone found in the four herbaceous plants: Scutellaria baicalensis, Scutellaria lateriflora, Oroxylum indicum, and the well-known species Thymus vulgaris (thyme). Recently recognized as a potential anticancer therapeutic agent, baicalein is gaining popularity in cancer research laboratories. However, it is unclear whether baicalein can inhibit cancerous properties of the human ERα-positive breast carcinoma cell line T47D. Here we demonstrate that baicalein can significantly inhibit cell growth and proliferation. Additionally, cell cycle analysis reveals that baicalein inhibits T47D breast cancer cell growth by inducing cell cycle arrest, suppressing colony formation and cell migration. Additionally, baicalein was shown to induce cell death by regulating genes and interacting with signaling pathways involved in apoptosis. These studies clearly suggest that baicalein has potent anti-cancer properties and has great potential for cancer therapy.

Support or Funding Information

Department of Natural Sciences, University of Michigan-Flint

*Correspondence: Dr. Besa Xhabija, xhabija@umich.edu

lt;p dir="ltr"gt;Department of Natural Sciences, University of Michigan-Flintlt;/pgt;lt;p dir="ltr"gt;*Correspondence: Dr. Besa Xhabija, xhabija@umich.edult;/pgt;lt;divgt;lt;brgt;lt;/divgt;