Location: Exhibit/Poster Hall A-B - Pennsylvania Convention Center
Poster Board Number: A390
Hahn Nahmgoong (Seoul National University), Yong Geun Jeon (Seoul National University), Eun Seo Park (DGIST), Yoon Ha Choi (DGIST), Sang Mun Han (Seoul National University), Jeu Park (Seoul National University), Yul Ji (Seoul National University), Jee Hyung Sohn (Seoul National University), Ji Seul Han (Seoul National University), Ye Young Kim (Seoul National University), Injae Hwang (Seoul National University), Yun Kyung Lee (Seoul National University College of Medicine amp; Seoul National University Bundang Hospital), Jin Young Huh (Seoul National University), Sung Sik Choe (Seoul National University), Tae Jung Oh (Seoul National University College of Medicine amp; Seoul National University Bundang Hospital), Sung Hee Choi (Seoul National University College of Medicine amp; Seoul National University Bundang Hospital), Jong Kyoung Kim (DGIST, DGIST), Jae Bum Kim (Seoul National University)
Presenting Author Seoul National University, Republic of Korea
In mammals, white adipose tissues are largely divided into visceral epididymal adipose tissue (EAT) and subcutaneous inguinal adipose tissue (IAT) with distinct metabolic properties. Although emerging evidence suggests that subpopulations of adipose stem cells (ASCs) would be important to explain fat depot differences, ASCs of two fat depots have not been comparatively investigated. Here, we characterized heterogeneous ASCs and examined the effects of intrinsic and tissue micro-environmental factors on distinct ASC features. We demonstrated that ASC subpopulations in EAT and IAT exhibited different molecular features with three adipogenic stages. ASC transplantation experiments revealed that intrinsic ASC features primarily determined their adipogenic potential. Upon obesogenic stimuli, EAT specific SDC1+ ASCs promoted fibrotic remodeling, whereas IAT-specific CXCL14+ ASCs suppressed macrophage infiltration. Moreover, IAT-specific BST2high ASCs exhibited a high potential to become beige adipocytes. Collectively, our data broaden the understanding of ASCs with new insights into the origin of white fat depot differences.
This study was supported by the National Research Foundation, funded by the Korean government (Ministry of Science and ICT; 2017M3A9B6073099 and 2020R1A2C400163011 to J.K.K. and NRF 2018R1A5A1024340 and NRF-2020R1A3B2078617 to J.B.K.). H.N., Y.G.J., S.M.H., J.P., Y.J., J.H.S., J.S.H., and Y.Y.K. were supported by the BK21 Plus program.
