(557.1) Study on changes of cardiac function and peripheral vascular resistance in elderly patients with hypertension

Poster Board Number: E124

Chunyan Hao (The First Hospital of Shanxi Medical University), Shuang Yang (The First Hospital of Shanxi Medical University), Mingli Li (The Eleventh Clinical College of Shanxi Medical university), Hubin Duan (The First Hospital of Shanxi Medical University, The First Hospital of Shanxi Medical University, The First Hospital of Shanxi Medical University)

Objective To investigate the changes of cardiac function and peripheral vascular resistance in elderly patiants with hypertention and their correlation with homocysteine (Hcy) and lipid levels.

Methods 126 hypertensive patients aged ≥60 years in the department of geriatrics, the first hospital of shanxi medical university from October 2017 to March 2019 were selected as the hypertension group, and 107 healthy patients aged ≥60 years in the same period were selected as the control group（The clinical study has passed ethical review）. Serum Hcy and lipid levels in the two groups were measured, and parameters of cardiac function and peripheral vascular resistance were recorded by non-invasive hemodynamic detector. The changes of Hcy, lipid profile, cardiac function and peripheral vascular resistance parameters in the two groups were compared, and the correlation between cardiac function and peripheral vascular resistance parameters and Hcy and lipid profile was analyzed.

Results Hcy, total cholesterol (TC), triglyceride (TG) and low-density lipoprotein cholesterol (LDL-C) in the hypertension group were higher than those in the control group (Plt;0.05), while high-density lipoprotein cholesterol (HDL-C) was lower than those in the control group (Plt;0.05). Peripheral vascular resistance (SSVR) and systemic resistance (SVR) in the hypertensive group were higher than those in the control group (Plt;0.05), and cardiac function parameters (CO), SV, LSW and LVET were lower than those in the control group (Plt;0.05). Pearson correlation analysis showed that hypertension group CO and Hcy in cardiac output, and negatively correlated with TC, LDL-C, stroke volume SV and negatively correlated with Hcy, left ventricular stroke work LSW and negatively correlated with Hcy, LDL-C, left ventricular ejection time (LVET )and negatively correlated with Hcy, peripheral vascular resistance index SSVR, SVR and Hcy, TC, TG, LDL-C were positively correlated, and negatively correlated with the SVR and HDL-C.

Conclusion In elderly patients with hypertension, cardiac function, including cardiac displacement and myocardial contractility, was significantly reduced, and peripheral vascular resistance was significantly increased. Moreover, such hemodynamic disorder was associated with Hcy and lipid levels.

[Key words] Hypertension; Homocysteine; Hemodynamic; Correlation

This study was supported by the Scientific research project of Shanxi Provincial Health Commission，Science and Technology Project for overseas Students of Shanxi Human Resources and Social Security Department，The Shanxi Province Basic Research Program,The Teaching Reform Program of Shanxi Higher Education.