While the thin-film transistor continues to evolve, producing devices with higher mobility, steeper sub-threshold slope, and lower threshold voltage, practical-signal processing circuits are constrained by issues related to non-uniformity, electrically and illumination-induced instability, and temperature dependence. This seminar will review the critical design considerations of displays, sensors, and sensor interfaces, along with advanced signal-processing architectures to show how device-circuit interactions should be handled and how compensation methods can be implemented. A key design consideration in flexible electronics, particularly for wearables and sensing applications, is low voltage, low-power operation. This requirement not only serves to maximize battery lifetime but crucially ensures operational stability of thin-film transistor (TFT) circuits and systems. Ultralow voltage/current operation is especially important in sensor interfaces to achieve a high resolution of the sensory signal. Nathan will present TFT design and materials selection strategies for ultralow power operation along with processing conditions for suppressing the interface trap density.