Session 7: GIST & Other Sarcomas with Actionable Targets

Chair(s)

• 

  Sebastian Bauer, MD (he/him/his)

  Director Sarcoma Center
  Department of Medical Oncology, Sarcoma Center, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen and German Cancer Consortium (DKTK), Partner Site University Hospital Essen, Essen, Germany
  Essen, Nordrhein-Westfalen, Germany

Moderator(s)

• 

  Ping Chi, MD, PhD (she/her/hers)

  Associate Member and Attending Physician
  Memorial Sloan Kettering Cancer Center
  New York, New York, United States
• 

  Armelle Dufresne, MD PhD

  Medical Oncologist
  Medical Cancer Department, Centre Léon Bérard
  Lyon, Auvergne, France

Presentations:

• 10:30 AM – 10:38 AM

  A NOVEL PROGNOSTICATION SYSTEM FOR PATIENTS WITH HIGH-RISK KIT EXON 9-MUTATED GASTROINTESTINAL STROMAL TUMOUR RECEIVING ADJUVANT IMATINIB
  

  Author: Andrea Napolitano, MD, PhD (he/him/his) – The Royal Marsden NHS Foundation Trust

  Co-Author: Sebastian Bauer, MD (he/him/his) – Department of Medical Oncology, Sarcoma Center, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen and German Cancer Consortium (DKTK), Partner Site University Hospital Essen, Essen, Germany

  Co-Author: Piotr Rutkowski, MD, PhD – Department of Soft Tissue/Bone Sarcoma and Melanoma; Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland

  Co-Author: Jean-Yves Blay, MD, PhD (he/him/his) – Centre Léon Bérard and Université Claude Bernard, Lyon, France

  Co-Author: Peter Reichardt, MD, PhD (he/him/his) – Helios Klinikum Berlin-Buch

  Co-Author: Heikki Joensuu, N/A, MD, PhD – Helsinki University Central Hospital and University of Helsinki

  Co-Author: Arun S. Singh, MD – University of California at Los Angeles

  Co-Author: Michael C. Heinrich, MD – Oregon Health and Science University

  Co-Author: Thomas Sutton, MD (he/him/his) – Oregon Health and Science University

  Co-Author: Denisse Montoya, MSc (she/her/hers) – The Life Raft Group

  Co-Author: Elena R. Fumagalli, N/A, MD – Istituto Nazionale Tumori

  Co-Author: Antoine Italiano, N/A, MD, PhD – Institut Bergonié

  Co-Author: Giovanni Grignani, MD – Department of Medical Oncology-Sarcoma Unit, Candiolo Cancer Institute FPO-IRCCS, Candiolo (TO), Italy

  Co-Author: Antonella Brunello, MD PhD (she/her/hers) – Veneto Institute of Oncology IOV – IRCCS

  Co-Author: Maria A. Pantaleo, N/A, MD – DIMES

  Co-Author: Winan J. Van Houdt, MSc, MD, PhD – The Netherlands Cancer Institute

  Co-Author: Nikki IJzerman, MD – Netherlands Cancer Institute and Erasmus MC Cancer Institute

  Co-Author: Neeltje Steeghs, N/A, MD – The Netherlands Cancer Institute

  Co-Author: Hans Gelderblom, MD, PhD – Leiden University Medical Center, Leiden, Netherlands

  Co-Author: Ingrid Desar, N/A, MD – Radboud University Medical Centre

  Co-Author: Javier Martín-Broto, MD, PhD – Fundacíon Jiménez Díaz University Hospital, ATBSARC lab in General Hospital of Villalba, IIS-FJD, Madrid, Spain

  Co-Author: Peter Hohenberger, N/A, MD – University Hospital Essen

  Co-Author: Axel Le Cesne, MD – Department of Medicine, Gustave Roussy

  Co-Author: Robin L. Jones, N/A, MD, PhD – The Royal Marsden NHS Foundation Trust

  Co-Author: Angelo Dei Tos, N/A, MD, PhD – Azienda Ospedaliera di Padova

  Co-Author: Alessandro Gronchi, MD, FSSO (he/him/his) – Fondazione IRCCS Istituto Nazionale dei Tumori

  Co-Author: Robert G. Maki, MD, PhD – Abramson Cancer Center

  Co-Author: Jonathan C. Trent, MD, PhD – University of Miami/Sylvester Comprehensive Cancer Center

  Co-Author: Paolo G. Casali, MD – University of Milan

  Co-Author: Bruno Vincenzi, Medical Oncologist, MD, PhD – Campus Bio-Medico University of Rome
• 10:38 AM – 10:46 AM

  REFINING PROGNOSIS IN LOCALIZED GIST: CLINICAL SIGNIFICANCE OF PTEN LOW EXPRESSION AND GENE LOSS
  

  Author: Xiaolan Feng, MD PhD FRCPC – Cumming School of Medicine, University of Calgary, Tom Baker Cancer Center

  Co-Author: haocheng Li, NA, PhD – 3. Department of Mathematics and Statistics, University of Calgary,

  Co-Author: Fourquet Fourquet, NA, PHD – 3. OncoSarc, INSERM U1037, Cancer Research Center in Toulouse,

  Co-Author: Mehdi Brahmi, MD PhD (he/him/his) – Department of Medical Oncology, Centre Léon Bérard,

  Co-Author: Armelle Dufresne, MD PhD – Medical Cancer Department, Centre Léon Bérard

  Co-Author: Alexandra Meurgey, N/A, MD – Department of Pathology, Centre Léon Bérard

  Co-Author: Isabelle Ray-Coquard, NA, MD PhD – Department of Medical Oncology, Centre Léon Bérard,

  Co-Author: Qing Wang, NA, MD PhD – Department of Pathology, Institut Claudius Régaud, IUCT-Oncopole, Toulouse,

  Co-Author: Julien Bollard, PhD – Research and Innovation, Centre Léon Bérard

  Co-Author: Francoise Fucimetiere, NA, PhD – Department of Oncology, Centre Léon Bérard

  Co-Author: Frederic Chibon, NA, PhD – 8. OncoSarc, INSERM U1037, Cancer Research Center in Toulouse and Department of Pathology, Institut Claudius Régaud, IUCT-Oncopole,

  Co-Author: Jean-Yves Blay, MD, PhD (he/him/his) – Centre Léon Bérard and Université Claude Bernard, Lyon, France
• 10:46 AM – 10:54 AM

  MULTI-OMIC INTEGRATIVE PROFILING OF MINIGISTS AND CLINICALLY RELEVANT GISTS THROUGHOUT PROGRESSION
  

  Author: Joanna Przybyl, PhD (she/her/hers) – McGill University

  Co-Author: Andrew J. Yim (he/him/his) – McGill University

  Co-Author: Mina Farag, MD, MSc – McGill University

  Co-Author: Shirley Zhu, MD, MPH – Stanford University

  Co-Author: Sushama Varma, MSc – Stanford University

  Co-Author: Sujay Vennam, BSc – Stanford University

  Co-Author: Sungmi Jung, MD – McGill University

  Co-Author: Piotr Rutkowski, MD, PhD – Department of Soft Tissue/Bone Sarcoma and Melanoma; Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland

  Co-Author: Maria Debiec-Rychter, MD, PhD (she/her/hers) – KU Leuven

  Co-Author: Matt Van De Rijn, MD, PhD (he/him/his) – Stanford University
• 10:54 AM – 11:02 AM

  ANTI-TUMOR EFFECTS OF THE NOVEL KIT MUTANT INHIBITOR M4205/IDRX-42 IN GASTROINTESTINAL STROMAL TUMOR (GIST) XENOGRAFT MODELS
  

  Author: Patrick Schöffski, MD, MPH – Laboratory of Experimental Oncology, Department of Oncology, KU Leuven, Leuven Cancer Institute

  Co-Author: Luna De Sutter, MA (she/her/hers) – Laboratory of Experimental Oncology, Department of Oncology, KU Leuven, Leuven Cancer Institute

  Co-Author: Jasper Verreet, N/A, n/a – Laboratory of Experimental Oncology, Department of Oncology, KU Leuven, Leuven Cancer Institute

  Co-Author: Ulla Vanleeuw – Laboratory of Experimental Oncology, Department of Oncology, KU Leuven and Department of General Medical Oncology, University Hospitals Leuven, Leuven Cancer Institute

  Co-Author: Lore De Cock, MD – Laboratory of Experimental Oncology, Department of Oncology, KU Leuven, Leuven Cancer Institute

  Co-Author: Nina Linde, N/A, MD – The healthcare business of Merck KGaA

  Co-Author: Christine Drechsler, N/A, MD – The healthcare business of Merck KGaA

  Co-Author: Christina Esdar, PhD (she/her/hers) – The healthcare business of Merck KGaA

  Co-Author: Raf Sciot, N/A, MD, PhD – Department of Pathology, KU Leuven and University Hospitals Leuven

  Co-Author: Agnieszka Wozniak, PhD, DSc (she/her/hers) – Laboratory of Experimental Oncology, Department of Oncology, KU Leuven and Department of General Medical Oncology, University Hospitals Leuven, Leuven Cancer Institute
• 11:02 AM – 11:21 AM

  Q&A
• 11:21 AM – 11:29 AM

  LONG-TERM EFFICACY AND SAFETY OF PEXIDARTINIB IN PATIENTS WITH TENOSYNOVIAL GIANT CELL TUMOR: RESULTS FROM THE PHASE 3 ENLIVEN STUDY
  

  Author: Andrew J. Wagner, MD, PhD – Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA

  Co-Author: William D. Tap, MD – Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, NY, USA

  Co-Author: Sebastian Bauer, MD (he/him/his) – Department of Medical Oncology, Sarcoma Center, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen and German Cancer Consortium (DKTK), Partner Site University Hospital Essen, Essen, Germany

  Co-Author: Jean-Yves Blay, MD, PhD (he/him/his) – Centre Léon Bérard and Université Claude Bernard, Lyon, France

  Co-Author: Jayesh Desai, FRACP – Peter MacCallum Cancer Centre, Melbourne, VIC, Australia

  Co-Author: Hans Gelderblom, MD, PhD – Leiden University Medical Center, Leiden, Netherlands

  Co-Author: Emanuela Palmerini, MD – IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy

  Co-Author: Christopher W. Ryan, MD – Oregon Health and Science University Knight Cancer Institute, Portland, OR, USA

  Co-Author: Charles Peterfy, MD, PhD – Spire Sciences, Boca Raton, FL, USA

  Co-Author: John H. Healey, MD, FACS – Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, NY, USA

  Co-Author: Michiel van de Sande, MD, PhD (he/him/his) – Leiden University Medical Center, Leiden, Netherlands

  Co-Author: Meng Qian, PhD – Daiichi Sankyo, Inc, Basking Ridge, NJ, USA

  Co-Author: Dale Shuster, PhD – Daiichi Sankyo, Inc, Basking Ridge, NJ, USA

  Co-Author: Xin Ye, PhD – Daiichi Sankyo, Inc., Basking Ridge, NJ, USA

  Co-Author: Silvia Stacchiotti (she/her/hers) – Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
• 11:29 AM – 11:37 AM

  INTRA-ARTICULAR INJECTIONS OF AMB-05X, A POTENT, SELECTIVE, HUMAN MONOCLONAL ANTIBODY AGAINST COLONY STIMULATING FACTOR 1 RECEPTOR FOR THE TREATMENT OF TENOSYNOVIAL GIANT CELL TUMOR
  

  Author: Michiel van de Sande, MD, PhD (he/him/his) – Leiden University Medical Center, Leiden, Netherlands

  Co-Author: Thomas J. Scharschmidt, N/A, MD – Ohio State University Wexner Medical Center

  Co-Author: Oleg Kostogryz, N/A, MD – National Academy of Medical Sciences

  Co-Author: Kirsten van Langevelde, N/A, MD – Leiden University Medical Center

  Co-Author: Michele Calleja, N/A, MD – Royal National Orthopaedic Hospital NHS Trust

  Co-Author: Earl Brien, MD – Cedars-Sinai Medical Center

  Co-Author: Kirk Johnson, N/A, PhD – AmMax Biopharma

  Co-Author: Michael Huang, MD – AmMax Biopharma

  Co-Author: Hans Gelderblom, MD, PhD – Leiden University Medical Center, Leiden, Netherlands
• 11:37 AM – 11:45 AM

  INTERACTIONS IN CSF1-DRIVEN TENOSYNOVIAL GIANT CELL TUMORS
  

  Young Investigator Award Winner: David GP van IJzendoorn, MD/PhD – Stanford University

  Author: David GP van IJzendoorn, MD/PhD – Stanford University

  Co-Author: Magdalena Matusiak, PhD – Stanford University

  Co-Author: Gregory W. Charville, MD/PhD – Stanford University

  Co-Author: Geert Spierenburg, MD (he/him/his) – Leiden University Medical Center

  Co-Author: Sushama Varma, MSc – Stanford University

  Co-Author: Deana R. Colburg, BSC – Stanford University

  Co-Author: Michiel van de Sande, MD, PhD (he/him/his) – Leiden University Medical Center, Leiden, Netherlands

  Co-Author: Kirsten van Langevelde, N/A, MD – Leiden University Medical Center

  Co-Author: David G. Mohler, MD/PhD – Stanford University

  Co-Author: Kristen N. Ganjoo, MD – Stanford Cancer Center, Stanford University

  Co-Author: Nam Bui, MD – Stanford University

  Co-Author: Raffi S. Avedian, MD/PhD – Stanford University

  Co-Author: J.V.M.G. Bovee, MD, PhD – Department of Pathology, Leiden University Medical Center

  Co-Author: Robert Steffner, MD/PhD – Stanford University

  Co-Author: Robert B. West, MD/PhD – Stanford University

  Co-Author: Matt Van De Rijn, MD, PhD (he/him/his) – Stanford University
• 11:45 AM – 12:00 PM

  Q&A