(P 082) PATIENT-REPORTED OUTCOME MEASURES TO MEASURE HEALTH-RELATED QUALITY OF LIFE IN PEOPLE WITH SOFT-TISSUE SARCOMA: A SYSTEMATIC REVIEW OF MEASUREMENT PROPERTIES OF PATIENT-REPORTED OUTCOMES

Objective: Patient-reported outcomes measures (PROMs) provide valuable information and are increasingly used in clinical care and measure what matters to the patient population. Various generic and disease specific PROMs are developed for cancer. This has results in rapid update on PROMs in clinical care for soft-tissue sarcoma (STS) with limited information on their psychometric properties. COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) steering committee developed a checklist to evaluate psychometric properties of PROMs. The purpose of this study is to systematically review study quality that have reported psychometric properties of PROMs used in STS using COSMIN criteria and provide evidence as to whether studies adhere to standardized reporting guidelines. The results of this study will be useful in selecting the optimal PROM for STS.

Methods: A systematic search was conducted in PubMed, Ovid Medline, CINAHL, EMBASE and the Cochrane Library between 2000 and 2018. The studies that assess the quality of PROMs in STS and published in English language were identified. Two reviewers will independently read the abstract and identified relevant full-text articles. The quality of the PROMs questionnaires will be evaluated using COSMIN checklist by the same two reviewers independently and any conflicts between them will be resolved in consultation with the third reviewer. Relevant data will be extracted from the studies related to constructs measures, content of the PROM, number of items or domains, psychometric information and other characteristics of the study as relates to patient demographics. The methodological quality of each study will be evaluated for risk of bias on 4-point ordinal scale (excellent, good, fair, or poor) and also on COSMIN checklist for each of 9 measurement properties.

Results: We have completed the systematic search and in process of extracting relevant information from each included studies. This project is on-going and findings will be presented at the conference.

Conclusion: Studies that report psychometric properties of PROMs are recommended to use COSMIN checklist so as to make sure that important information related to the measure is made available to the reader. This project will highlight any gaps related to reporting of PROMs in STS and provide information on which PROMs should be used for trials.