Bioinformatics unit
Department of Biosciences, University of Milan and Italian Institute for Genomic Medicine (Candiolo, Turin)), Italy
I am Serena Peirone. I was born in Saluzzo, Italy, on the 18th of April, 1994. I graduated in Physics at the University of Turin studying the climatology of vineyard phenological phases in Piemonte region based on observed temperature records in 2016. Then, I took my master degree in Physics of Complex Systems in the same university studying the alterations of regulatory networks between transcription factors and RNA-binding proteins in 2018. I ended PhD cum laude in Complex Systems for Life Sciences (University of Turin) in March, 2022, studying the tissue specific transcriptional regulation of splicing factors. In the meantime, in early 2021 I joined the bioinformatics unit that performs the sequencing analyses of the Italian clinical trial SAR-GEN_ITA (clinicalgov.com ID: NCT04621201). After my PhD I became a fellow, first at Italian Institute for Genomic Medicine (Candiolo, TO) and then at the University of Milan, in the Biosciences department. I deal with RNA/DNA sequencing data analysis, Methylated RNA immunoprecipitation sequencing data, identification of protein binding sites using chromatin immunoprecipitation sequencing and assay for transposase-accessible chromatin sequencing data. I am interested in alternative splicing landscape and regulation and in network analysis. My main task is to evaluate through statistical and modelling methods the dysregulated molecular mechanisms in cancer. I am also interested in searching for novel events that can be potentially targeted through RNA therapeutics. My aim is to give my contribute in the long way of disentangling cancer mechanisms of development and resistance.