(P 274) AMPUTATION IN PATIENTS WITH EXTREMITY SOFT TISSUE SARCOMA: THE EXPERIENCE OF AN EAST ASIAN REFERRAL CENTER

Objective: Because of the Confucian influence in East Asia, patients are often reluctant to undergo amputation. This study aimed to investigate the characteristics and clinical outcomes in a series of patients with extremity STS who underwent amputation at a large East Asian referral center.

Methods: Of the 652 patients who underwent surgery for extremity STS, data of 37 consecutive patients who underwent amputation were reviewed. We assessed the amputation rate in patients with localized STS and the oncologic outcomes including disease-specific survival (DSS), local recurrence-free survival (LRFS), and metastasis-free survival (MFS) in the amputation group and limb salvage group.

Results: Approximately 3.6% (22/596) of patients with localized STS underwent amputation. Further, 1.8% (9/490) of patients with primary localized STS underwent amputation, which was lower than the rates reported in Western studies. Patients with localized STS who underwent amputation had a 5-year DSS rate of 89.9%, an LRFS of 84.1%, and an MFS of 84.6%. Compared with previous studies, our results showed higher DSS and MFS rates with similar LRFS. The primary localized (PL) group had a 5-year DSS of 85.7%, an LRFS of 87.5%, and an MFS of 87.5%. The recurrent localized (RL) group had a 5-year DSS of 92.3%, an LRFS of 81.8%, and an MFS of 82.1%.

Conclusion: The amputation rate of patients with extremity STS in East Asian studies was lower than that in Western studies, while the oncologic outcome of amputation reported in East Asian studies was superior to that reported in Western studies.