(P 212) COMPARISON OF SURGICAL OUTCOMES BETWEEN LEIOMYOSARCOMA OF INFERIOR VENA CAVA AND OTHER LOCATIONS

Objective: Primary leiomyosarcoma (LMS) of inferior vena cava (IVC) is rare, but the prognosis is poor due to frequent invasion of adjacent structures. Surgery is the only potential treatment for LMS of IVC, but surgical resection remains a challenge. In this study, we compared the outcomes after resection of LMS of IVC with LMS of other locations. Also, we evaluated the patency of the graft used for IVC reconstruction.

Methods: All patients who underwent surgery for LMS from September 2001 and April 2020 were retrospectively reviewed. In the LMS of the IVC group, all patients underwent complete gross resection of the tumor with the involved IVC for curative intention. Reconstruction of the IVC was performed in all patients by patch or interposition using autograft, allograft, or polytetrafluoroethylene (PTFE) graft.

Results: Seven patients (16.7%, 7/42) were included in the LMS of the IVC group, and 35 patients (83.3%, 35/42) were included in the LMS of other locations group. The operation time was significantly longer in the LMS of the IVC group than the LMS of other locations group (p = 0.029). However, the postoperative complication and Clavien-Dindo 3 or higher complication rates were similar between the LMS of IVC group and LMS of other locations group (p = 0.063 and 0.309, respectively). Also, the 5-year overall survival and disease-free survival were similar between the two groups (p = 0.896 and 0.815, respectively). Only one case that used allograft for interposition was occluded 4 months after the operation.

Conclusion: The resection of LMS of IVC may achieve outcomes equivalent to resection of LMS of other locations.