Introduction: We sought to analyze the association between various lifestyle and environmental factors and the occurrence of muscle invasive (MIBC) versus non muscle invasive bladder cancer (NMIBC).
Methods: A total of 582 consecutive patients with bladder cancer completed a comprehensive questionnaire that encompassed different lifestyle and environmental risk factors for bladder cancer which included smoking status, primary source of drinking water, a personal history of any previous genitourinary cancers, and environmental exposure to lead or asbestos, paint, rubber, and hair dyes. Patients were divided into MIBC and NMIBC. Descriptive statistics were used to summarize the data. Multivariable analysis (MVA) was performed to investigate the association between lifestyle and environmental factors, and the occurrence of MIBC versus that of NMIBC.
Results: Median age was 71 years (IQR 64-78); 76% were males and 95% were Caucasians. Forty-one percent of patients had MIBC at presentation. Of all patients, 76% had history of smoking, wells were the source of drinking water in 13%, and 40% had history of environmental exposure. There was no difference in lifestyle and environmental exposures between MIBC and NMIBC. (Table 1). Having a history of previous genitourinary cancers (OR 0.32, 95%CI 0.10–0.98, p-value=0.05) and older age (OR 1.02, 95%CI 1.01-1.04, p-value < 0.01) were associated with higher risk of MIBC (Table 2).
Conclusions: Lifestyle factors and environmental exposures did not significantly differ between patients with MIBC and NMIBC. History of genitourinary cancer and older age were associated with MIBC.
Source of Funding: Roswell Park Alliance Foundation
.jpg)
.jpg)
