.jpg)
.jpg)
.jpg "Hao G. Nguyen, MD, PHD photo")
University of California, San Francisco
I received the MD, PhD combined degree from Boston University and Urology residency training at UC Davis. I was recruited to join the UCSF faculty as Assistant Professor after completed the fellowship and trained as a urologic oncology surgeon under Dr. Peter Carroll. My research project has already shown incredible potential to uncover novel molecular therapeutic targets for the treatment of advanced prostate cancer. As a promising young surgeon-scientist, I was awarded the DOD grant to interrogate the distinct ability of cancer cells to upregulate their stress response pathways upon oncogenic stress, chemotherapy and radiotherapy in order to evade cell death. I delineated the mechanisms underlying stress response pathways, in particular the unfolded protein response (UPR) and define their role in prostate tumorigenesis using genetic mouse models as well as in patient derived xenografts model of metastatic prostate cancer. My main research program was recently published in a high impact publication in Science Translational Medicine and resulted in a patent on the use of biomarker PTEN loss and high phospho eIF2α to identify lethal prostate cancer who may benefit from anti-eIF2α therapy. In 2016, I received the PCF young investigator award and the AUA Rising Star in Research award to develop patient derived xenograft (PDX) models to evaluate novel therapies for patients with neuroendocrine metastatic prostate cancer. In 2020, I received the 1 million-dollar PCF Challenge Grant to bring novel therapeutics for metastatic prostate cancer. I had published more than 65 journal articles. In addition to basic science, my clinical interest focuses on early detection of prostate cancer using advance imaging (PSMA PET), novel biomarkers and MRI fusion biopsy in early diagnosis and treatment of prostate cancer. In 2019, I was appointed Benioff-Goldberg Endowed Professorship in Cancer Biology and the recipient of the William R. Smart M.D Distinguished Teaching Award.
Disclosure information not submitted.