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Boston Children's Hospital and Harvard Medical School
Rosalyn Adam, PhD is Director of Urology Research at Boston Children's Hospital and Associate Professor of Surgery at Harvard Medical School. She is a cell biologist and biochemist by training. Dr. Adam's research focuses on understanding the molecular basis of hollow organ pathobiology, with a focus on tissue remodeling and alterations in smooth muscle physiology, but also with interests in tumor biology and cancer progression. The major areas of interest in her laboratory are: (1) characterization of mechanosensitive signaling networks and regulation/targeting of mechanosensitive transcriptional complexes including AP-1 and MYC in physiologically relevant models of urinary tract obstruction; (2) the elucidation of neuropilin 2-dependent signaling in smooth muscle contractility and relaxation in the urinary tract, and the exploitation of this axis to modulate smooth muscle contractility in the setting of urinary tract obstruction; (3) delineation of the mechanisms of action of the purine nucleoside inosine in mitigation of detrusor overactivity following spinal cord injury, and optimization of strategies for its clinical use in patients; (4) investigation of mechanisms regulating receptor tyrosine kinase signaling in bladder cancer, and the role of the EGFR/c-MET regulator endophilin A1 in regulation of sensitivity to tyrosine kinase inhibitors.
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Friday, May 13, 2022
10:30 AM – 11:45 AM