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Professor Emeritus of Urology
University of California San Diego
C. Lowell Parsons MD, Professor Emeritus of Surgery/Urology, University of California San Diego. My research interests are in intestitial cystitis (IC) and I have performed extensive clinical and basic laboratory research on this topic for over 38 years. This research has resulted in the discovery that bladder surface mucus (GAG layer) regulates the permeability of the urinary bladder and it is abnormal in IC patients and leaks. The research also provide solid evidence that once the epitheilum is dysfunctional potassium leaks into the bladder wall and causes symptoms and tissue injury. The leak was found to be reversed by heparin and pentosanpolysulfate (PPS) and resulted in the approval of PPS for IC in the USA. Additonal research showed that the epithelium leaks potassium into the interstitium of the bladder in patients with gynecologic pelvic pain, endometriosis, vulvadynia, prostatitis,overactive bladder and urethral syndrome essentially uniting all of these diagonses into one disease, lower urinary dysfunctional epithelium. These findinngs have created an entirely new paradigm in that there is one disease process responsible for the generation of bladder symptoms in 80% of females of all ages and most men less than 55 years of age. Most recently we have discovered that toxic urinary cations, several nucleic acid metabolites and trytophan are markedly elevated in IC patients and they will injure the bladder mucus and initiate the epitheilal leak causing symptoms in IC and all of the other syndromes listed above. In essence these urinary metabolites are the cause of IC.
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Saturday, May 14, 2022
3:30 PM – 5:30 PM