PD13-02: Age‑independent secular baseline PSA population trends among young Latin American males

Diego M. Capibaribe, Walker W. Laranja, Wilmar Azal Neto, Danilo L. Andrade, Rodrigo G. Bocos, Natássia C. C. Truzzi, Campinas, Brazil, José C.C.I. Truzzi, Sao Paulo;, Brazil, Leonardo Reis*, Campinas, Brazil

Introduction: To broaden the understanding of possible baseline PSA variations over the last decades in young men.

Methods: PSA levels from 46,709 patients from a private diagnostic center aging 25 to 40 years old were prospectively collected between 2003 and 2018 in Brazil. Patients were distributed into three age groups (Group 1: 25-30 years, Group 2: 31-35 years, Group 3: 36-40 years). Data were analyzed using the Jonckheere–Terpstra with post hoc analysis and ANOVA with Tukey post hoc tests to rank values and establish upwards or downwards trends.

Results: Mean participant age and total PSA were 35.64 years and 0.77ng/dL, respectively. The mean/median age among PSA-tested men decreased from 36.32/37.23 in 2003 to 34.87/35.88 years old in 2018. On the contrary, the mean/median PSA values rose from 0.67/0.57 ng/dL in 2003 to 0.91/0.66 ng/dL in 2018, with a steady increase over the studied period at a rate of 0.015ng/dL of the median per year, p<0.0001. The PSA increase rate was 0.016 ng/dL per year (2.8%) in Group 1, 0.015 ng/dL (2.2%) in Group 2 and 0.017ng/dL (2.5%) rise per year in Group 3, all p<0.0001.

Conclusions: Mean participant age and total PSA were 35.64 years and 0.77ng/dL, respectively. The mean/median age among PSA-tested men decreased from 36.32/37.23 in 2003 to 34.87/35.88 years old in 2018. On the contrary, the mean/median PSA values rose from 0.67/0.57 ng/dL in 2003 to 0.91/0.66 ng/dL in 2018, with a steady increase over the studied period at a rate of 0.015ng/dL of the median per year, p<0.0001. The PSA increase rate was 0.016 ng/dL per year (2.8%) in Group 1, 0.015 ng/dL (2.2%) in Group 2 and 0.017ng/dL (2.5%) rise per year in Group 3, all p<0.0001.

Source of Funding: none