Introduction: Obstructive sleep apnea (OSA) is one of the major cause of nocturia. How nocturia affect patients with and without OSA on polysomnography (PSG) has not been well established. To clarify the association between nocturia and OSA, we analyzed PSG results of patients with different lower urinary tract symptoms and severity of OSA.
Methods: 141 male patients with suspected OSA received PSG examination. All patients were divided into 2 groups according to the present of nocturia. The International Prostate Symptom Score (IPSS) questionnaire, age, body mass index (BMI) and PSG parameters including whole-night total sleep time (TST), sleep efficiency (SE), Apnea/Hypopnea Index (AHI), and other factors of these patients were reviewed and analyzed between the two groups. Patients with AHI =5 was defined as OSA. Patients with AHI =15 and =30 was defined moderate and severe OSA respectively.
Results: In 141 male patients, there were 114 patients with OSA. 49 patients had mild OSA, 33 patients had moderate OSA and 32 patients had severe OSA. In all patients, nocturia patients have higher frequency (P=0.035), worse quality of life (P <0.0001) and decreased baseline SaO2 (P=0.038) significantly. Nocturia did not affect quality of life (P=0.097) and baseline SaO2 (P=0.325) significantly in patients without OSA. In mild OSA patients, nocturia patients have higher frequency (P=0.028), worse quality of life (P <0.0001) and decreased baseline SaO2 (P=0.037) significantly. In moderate and severe OSA patients, nocturia patients have worse quality of life (P <0.0001) significantly. There was no statistic different in baseline SaO2 (P=0.093). In moderate OSA patients, nocturia patients have quality of life significantly (P=0.02) and no statistic different in baseline SaO2 (P=0.112). In severe OSA patients, nocturia patients have quality of life (P=0.042) and decreased baseline SaO2 (P=0.039) significantly.
Conclusions: Nocturia decreases baseline SaO2 and increase the risk of frequency significantly in patients with mild OSA or without OSA. Patient without OSA In patients with suspected OSA, nocturia increased frequency rate and worse quality of life significantly. For suspected OSA patients, especially in mild and severe OSA groups, more urological evaluation and treatment for nocturia is required.
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