Session/Event: Oh Baby! Gestational Stress and Social Determinants of Pre-conception, Pregnancy and Pediatrics (Oral 19)

(OR19-04-22) Assessing the Impact of Socioeconomic Status on Maternal and Cord Serum Omega-3 Polyunsaturated Fatty Acid Levels

On Demand

Presenting Author(s)

Alexandra J. Hergenrader, BS

Medical Student
University of Nebraska Medical Center
Omaha, Nebraska, United States

Disclosure: Disclosure(s): No relevant financial relationship(s) with ineligible companies to disclose.

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Co-Author(s)

MV

Matthew Van Ormer, BS

University of Nebraska Medical Center
Omaha, Nebraska, United States
MT

Maranda Thompson, BS

University of Nebraska Medical Center
Omaha, Nebraska, United States
RS

Rebecca Slotkowski

Graduate Student
University of Nebraska Medical Center
Omaha, Nebraska, United States
Alyssa Freeman, BA

Medical Student
University of Nebraska Medical Center
OP

Olivia Paetz

University of Nebraska Medical Center
Sarah Sweeney, BS, BA

Medical Student
University of Nebraska Medical Center
OMAHA, Nebraska, United States
Lauren Wegner, MS

Medical Student
University of Nebraska Medical Center
OMAHA, Nebraska, United States
KA

Khadijjta Ali

University of Nebraska Medical Center
NB

Nicole Bender

University of Nebraska Medical Center
RC

Ridhi Chaudhary

University of Nebraska Medical Center
MT

Melissa Thoene, PhD, RD

Assistant Professor
University of Nebraska Medical Center
Omaha, Nebraska, United States
CH

Corrine Hanson, PhD, RD, LMNT, FAND

Professor
University of Nebraska Medical Center
Omaha, Nebraska, United States
Ann Anderson-Berry, MD, PhD

Professor and Vice Chair of Research, Pediatrics
University of Nebraska Medical Center
Omah, Nebraska, United States

Objectives: Omega-3 (n-3) polyunsaturated fatty acids (PUFAs) are essential in fetal growth and development and have been shown to modulate inflammatory processes throughout the lifespan. Previous studies have demonstrated that individuals with lower socioeconomic status (SES) may be at risk for low intake of n-3 PUFAs, however, no research has compared the concentrations of these nutrients present in maternal and cord serum between markers of SES. The purpose of this study is to assess the relationship between markers of SES and levels of n-3 PUFAs in maternal and cord serum in a group of patients delivering at a Midwest Academic Medical Center.

Methods: An IRB-approved study enrolled mother-infant pairs (n=55) at the time of delivery for collection of maternal and cord serum samples. n-3 PUFA levels quantified included Eicosapentaenoic acid (EPA), Docosahexaenoic acid (DHA), and total n-3 PUFAs. Markers of SES include private vs public insurance, income ≤150% of the poverty line vs >150%, and college degree earners vs no college degree. The Mann-Whitney U test was used to assess differences in n-3 PUFA levels between SES groups. A p< 0.05 was considered statistically significant.

Results: Median gestational age at delivery was 39.3 weeks. Significantly higher nutrient levels were present in college-educated mothers vs less than college-educated mothers in median maternal EPA (9.44 µg/mL vs 5.13 µg/mL, p=0.010), cord EPA (1.88 µg/mL vs 1.40 µg/mL, p=0.011), cord DHA (37.96 µg/mL vs 32.80 µg/mL, p=0.014), and total cord n-3 PUFAs (44.23 µg/mL vs 39.34 µg/mL, p=0.024). Median cord EPA levels were significantly higher in those with private insurance compared to public (1.79 µg/mL, 1.18 µg/mL, p=0.022). Additionally, median cord EPA levels were significantly higher in those >150% the poverty line (1.79 µg/mL, 1.10 µg/mL, p=0.030).

Conclusions: Our findings suggest that individuals with lower SES may be at risk for lower serum levels of n-3 PUFAs in pregnancy, which could increase their susceptibility to adverse birth and pregnancy outcomes. Future studies should focus on replicating these results in a larger, more heterogeneous sample and should consider analyzing additional markers of SES.

Funding Sources: UNMC Pediatrics Department; Child Health Research Institute