(PO16-65-22) Food Creatine and Head Circumference Among Children Aged 0–2 Years

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Presenting Author(s)

Sergej M. Ostojic, MD, PhD
– Professor and Head of FSPE Applied Bioenergetics Lab, University of Novi Sad, Novi Sad, Vojvodina, Serbia

Co-Author(s)

DK

Darinka Korovljev
– University of Novi Sad
VS

Valdemar Stajer
– University of Novi Sad
NT

Nikola Todorovic
– University of Novi Sad

Disclosure(s):

Sergej M. Ostojic, MD, PhD: AlzChem: Advisory Committee/Board Member (Ongoing)
AlzChem GmbH: Grant/Research Support (Ongoing)
Hueston Hennigan LLP: Grant/Research Support (Terminated)
ThermoLife International LLC: Grant/Research Support (Terminated)

Objectives: Several small-scalle studies demonstrated an association between dietary creatine intake and body size in school-aged children and adolescents, yet no such connection has been evaluated in very young children at the populational level. We conducted a secondary analysis of previously completed cross-sectional study, and determined an association between food creatine and body measures in 597 U.S children aged 0 to 2 years, using the 2017-2018 National Health and Nutrition Examination Survey database.

Methods: Total grams of creatine consumed per day were computed using the average amount of creatine (e.g., 0.20 g/kg for milk-based foods and 3.88 g/kg for meat-based sources) across all creatine-containing food sources.

Results: Dietary creatine intake was positively correlated with head circumference (r = 0.184; P = 0.031) when controlled for age at screening, while no link was found between creatine consumption and recumbent length (r = - 0.003; P = 0.955) or body weight (r = 0.048; P = 0.317). A multiple regression analysis revealed a significant relationship between food creatine and head circumference (P < 0.001) when adjusted for the effects of selected dietary variables (e.g., weight of food consumed, total caloric content, protein intake).

Conclusions: Our findings indicate a relationship between food creatine and head circumference as a surrogate marker of brain size in early childhood; further pediatric studies should appraise the role of dietary creatine in neurodevelopment.

Funding Sources: N/A