(PO09-01-22) Erythrocyte Linoleic Acid Is Associated With Higher Heart Rate Variability and Better Sleep Quality: A Possible Link to Reducing Risk for Cardiometabolic Diseases

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Presenting Author(s)

Martha A. Belury, PhD, RDN
– Carol S. Kennedy Professor of Nutrition, The Ohio State University, Columbus, Ohio, United States

Co-Author(s)

RC

Rachel M. Cole, PhD RDN LD
– Research Associate, The Ohio State University, Columbus, Ohio, United States
RA

Rebecca Andridge, Ph.D
– Associate Professor, The Ohio State University, Columbus, Ohio, United States
AM

Annelise A. Madison
– The Ohio State University
JK

Janice K. Kiecolt-Glaser
– The Ohio State University

Disclosure(s):

Martha A. Belury, PhD, RDN: American Society for Nutrition: Executive Role (e.g. Board of Directors) (Ongoing)
Bath and Body Works: Consultant (Ongoing)
United Soybean Board: Grant/Research Support (Ongoing)

Rachel M. Cole, PhD RDN LD: No relevant financial relationship(s) with ineligible companies to disclose.

Objectives: Cancer patients often experience poor sleep quality, an aspect of health that accelerates the risk for cardiovascular and metabolic diseases. Higher intake of linoleic acid (LA: 18:2n-6) is linked with reduced risk for cardiometabolic diseases. This study has two objectives: To identify whether erythrocyte LA content is associated with sleep quality in women who were newly diagnosed with breast cancer; 2) Measure the association of erythrocyte LA with metabolism and postprandial heart rate variability (HRV).

Methods: In this cross-sectional study, erythrocyte LA levels were quantified at the same visit as measurements of body composition, self-reported sleep quality, HRV, postprandial energy metabolism and cardiorespiratory fitness (VO_2peak) in women (N=150) newly diagnosed with breast cancer. At a separate visit, cardiometabolic fitness was also measured.

Results: Erythrocyte LA was positively associated with higher appendicular lean mass (ALM/BMI) and higher pre-meal heart rate variability. In addition, higher erythrocyte LA was associated with better reported overall sleep quality. Postprandially, women with higher erythrocyte LA had a steeper decline of pulse and a less steep decline of glucose.

Conclusions: The positive relationship between LA with better sleep quality and higher heart rate variability supports the need to test whether fortifying the diet with LA-rich oils lowers cardiometabolic risk in cancer patients involving the autonomic nervous system.

Funding Sources: Funding was provided by the National Cattleman’s Beef Association (MAB), NIH (JKG) CA186720, Ohio Agriculture Research and Development Center (MAB) and the Carol S. Kennedy Professorship (MAB).