(PO22-17-22) The Role of Child Diets in the Association Between Pre-pregnancy Diets and Childhood Behavioral Problems: A Mediation Analysis

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Presenting Author(s)

Dereje Gete, PhD
– Postdoctoral Research Fellow , The University of Queensland, Brisbane, Queensland, Australia

Co-Author(s)

MW

Michael Waller, Doctor of Philosophy
– University of Queensland, Brisbane, Queensland, Australia
GM

Gita Mishra, Doctor of Philosophy
– University of Queensland, Brisbane, Queensland, Australia

Disclosure(s):

Dereje Gete, PhD: No relevant financial relationship(s) with ineligible companies to disclose.

Objectives: To quantify the mediating role of childhood diets in the association between maternal diets before pregnancy and offspring behavioral problems.

Methods: This study included 1448 mother-child pairs from the Australian longitudinal study on women’s health and its sub-study mothers and their children’s health. The healthy eating index score was constructed using a semi-quantitative and validated 101-item food-frequency questionnaire. Childhood behavioral problems were assessed using the strengths and difficulties questionnaire. Three dietary patterns were identified using principal component analysis to explore childhood dietary patterns (high fats and sugar; prudent diets; and diary). A causal inference framework for mediation analysis was used to quantify the mediating role of childhood diets in the association between pre-pregnancy diets and the risk of offspring behavioral problems.

Results: We found a 20% of the total effect of the poor adherence to pre-pregnancy diet quality on the risk of offspring behavioral problems was mediated through childhood high consumptions of fats and sugar. No clear mediating effect through prudent, and diary childhood diets was observed.

Conclusions: This study suggests that childhood high fats and sugar consumption may contribute to the total effects of the pre-pregnancy diets on the risk of childhood behavioral problems.

Funding Sources: The ALSWH is funded by the Australian Government Department of Health. MatCH is funded by the National Health and Medical Research Council (NHMRC) project grant. Dereje Gete is supported by the University of Queensland Research Training Scholarship. Gita Mishra holds the Australian Health and Medical Research Council Principal Research Fellowship.