(PO22-31-22) Associations of Circulating Levels of Trimethylamine N-oxide, Choline, Carnitine, and Betaine With Inflammatory Markers Among Breast Cancer Survivors

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Presenting Author(s)

YL

Yeon Jin Lee, MS
– Student, Seoul National University, Department of Food and Nutrition, College of Human Ecology, Seoul, Seoul-t'ukpyolsi, Republic of Korea

Co-Author(s)

SS

Sihan Song, PhD
– Seoul National University, Gwanak-gu, Ulsan-gwangyoksi, Republic of Korea
ZK

Zisun Kim, MD
– Soonchunhyang University College of Medicine, Bucheon, Kyonggi-do, Republic of Korea
HY

Hyun Jo Youn, MD, PhD
– Chonbuk National University Medical School, Jeonju, Cholla-bukto, Republic of Korea
JC

Jihyoung Cho, MD
– Keimyung University School of Medicine, Dalseo-gu, Taegu-jikhalsi, Republic of Korea
JM

Jun Won Min, MD, PhD
– Dankook University College of Medicine, Cheonan, Ch'ungch'ong-namdo, Republic of Korea
YK

Yoo Seok Kim, MD
– Chosun University College of Medicine, Dong-gu, Kwangju-jikhalsi, Republic of Korea
AF

Adrian A. Franke, PhD
– University of Hawaii Cancer Center, Honolulu, Hawaii, United States
JL

Jung Eun Lee, ScD
– Associate Professor, Seoul National University, Seoul, Seoul-t'ukpyolsi, Republic of Korea

Disclosure(s):

Yeon Jin Lee, M.S.: No relevant financial relationship(s) with ineligible companies to disclose.

Objectives: We examined the associations of circulating levels of trimethylamine N-oxide (TMAO) and its precursors (choline, carnitine, and betaine) with inflammatory markers in breast cancer survivors in Korea.

Methods: A total of 431 women (285 premenopausal breast cancer) aged 30-78 years were included. Least-squares mean (LS-mean)s and 95% confidence interval (CI)s were estimated for plasma levels of high-sensitivity C-reactive protein (hs-CRP), interleukin (IL)-6, IL-8, tumor necrosis factor-α (TNF-α), and adiponectin according to plasma levels of TMAO, choline, carnitine, and betaine, using the generalized linear models.

Results: Among premenopausal breast cancer survivors, increasing circulating levels of choline were associated with increasing levels of IL-6, IL-8, and TNF-α; LS-means (95% CIs) of the lowest and the highest quartiles were 0.75 (0.56-0.96) and 1.01 (0.80-1.24) pg/mL (p for trend = 0.019) for IL-6, 11.49 (8.19-15.97) and 17.73 (12.96-24.13) pg/mL (p for trend = 0.005) for IL-8, and 9.45 (7.47-11.88) and 11.99 (9.63-14.88) pg/mL (p for trend = 0.021) for TNF-α, respectively. Increasing plasma betaine levels were associated with increasing levels of adiponectin but decreasing levels of hs-CRP and IL-6; LS-means (95% CIs) of the lowest and the highest quartiles were 7.25 (5.65-9.23) and 9.05 (7.10-11.47) μg/mL (p for trend = 0.044) for adiponectin, 0.68 (0.45-0.96) and 0.35 (0.16-0.57) mg/L (p for trend 0.017) for hs-CRP, and 0.98 (0.77-1.21) and 0.75 (0.57-0.97) pg/mL (p for trend = 0.013) for IL-6, respectively. However, plasma levels of TMAO and its precursors were not significantly associated with inflammatory markers in postmenopausal breast cancer survivors.

Conclusions: In this cross-sectional study of breast cancer survivors, increasing plasma levels of choline were associated with increasing levels of inflammatory markers, but plasma levels of betaine were inversely associated with these markers among premenopausal breast cancer survivors.

Funding Sources: This work was supported by the National Research Foundation of Korea (NRF) grants funded by the Korea Government (Ministry of Science and ICT) (No. 2014R1A2A2A01007794, 2019R1F1A1061017, and 2021R1F1A1062476).