(PO11-08-22) Effect of Consuming a High Protein, High Fiber Shake on Measures of Satiety: A Randomized, Controlled, Cross-Over Study in Healthy Overweight and Obese Subjects

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Presenting Author(s)

Alexandra L. Jenkins, PhD RD
– Senior Scientist, INQUIS Clinical Research, Toronto, Ontario, Canada

Co-Author(s)

CM

Courtney McCormick, MPH, RDN, LDN
– Nutrisystem
ST

Sharon A. Tate, MS, Food and Nutritional Sciences
– Nutrisystem Inc
JC

Janice E. Campbell, MSc
– INQUIS Clinical Research Ltd
TW

Thomas MS Wolever, MD PhD
– Medical Director and Principal Scientist, INQUIS Clinical Research, Ltd., Toronto, Ontario, Canada

Disclosure(s):

Alexandra L. Jenkins, PhD RD: Anderson Advanced Ingredients: Independent Contractor (including contracted research) (Ongoing)
Nutrisystem: Independent Contractor (including contracted research) (Ongoing)

Thomas MS Wolever, MD PhD: INQUIS Clinical Research: Employee (Ongoing)

Objectives: To estimate the time for hunger scores to return to baseline levels for the Control and high protein, high fiber shakes.

Methods: A total of 80 subjects were recruited for this double-blind, randomized, controlled study (50F:30M; BMI 30.3±3.7kg/m²). Overnight fasted subjects consumed equicaloric portions (120kcal) of the high protein, high fiber Chocolate Nutrisystem shake (NSh) and a low protein, low fiber chocolate beverage (Control). For pre-menopausal females, both visits were scheduled during the follicular phase of their menstrual cycle. The motivation-to-eat questionnaire was completed before and at 15. 30, 45, 60, 90, 120, 150, 180, 210 and 240min after starting to consume the test meal. Throughout the 4.5h visit, participants were seated quietly and were not be allowed to use any electronic devices. Time to baseline and differences in scores for the 4 satiety questions (Hunger, Desire to Eat, Prospective Consumption and Fullness) and the Average Appetite were analyzed.

Results: Five subjects dropped out and n=75 were included in the final analysis. Per protocol analysis: Time to baseline for hunger scores after NSh, 183±11min, was the same as Control, 183±12min (n=53; NS), however time to return to baseline for Fullness after NSh , 218±10min, was greater than Control, 198±10min, (n=63; p=0.036). When all 75 subjects were included in the analysis, there was no difference for hunger, but time to baseline for Fullness after NSh, 3h and 20min (200±11min) was significantly longer than Control, 2h and 54min (174±11min, p=0.037). The percent of subjects whose ratings were still above baseline after 4h did not significantly differ for Hunger, Desire to Eat, Prospective Consumption or Average Appetite but was higher for Fullness after NSh, 44%, than Control, 28% (p=0.041).

Conclusions: Hunger scores remained above baseline for over 3h after a serving of Chocolate Nutrisystem shake and levels of fullness persisted for over 3.5h. Fullness levels were significantly greater after consumption of the Nutrisystem shake than Control. The Nutrisystem shake may therefore be a helpful aid to increasing feelings of fullness.

Funding Sources: Nutrisystem Inc