(PO01-01-22) Menopause Is a Key Factor Influencing Postprandial Metabolism, Metabolic Health and Lifestyle: The ZOE PREDICT Study

The ePoster content is available to NUTRITION 2022 LIVE ONLINE attendees who are logged in.<br><br>If you are registered, log in and then come back here to use this button.

Presenting Author(s)

KB

Kate M. Bermingham, Phd
– Post Doctoral Research Assistant, Kings College London, London, England, United Kingdom

Co-Author(s)

Inbar Linenberg, MSc
– Staff, King's College London, London, England, United Kingdom
AV

Ana Valdes, PhD
– University of Nottingham, nothingaam, England, United Kingdom
WH

Wendy Hall, BSc, PhD
– Reader, King's College London, London, England, United Kingdom
JoAnn E. Manson, MD, DrPH
– Chief, Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States
LN

Louise R. Newson
– Newson Health Research and Education
AC

Andrew Chan, MD, MPH
– Professor of Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States
KK

Kirstin Kade
– Zoe Ltd
PF

Paul Franks, PhD
– Lund University, Malmo, Dalarnas Lan, Sweden
JW

Jonathan Wolf, PhD
– ZOE Global, London, England, United Kingdom
Tim D. Spector, MD
– Director, TwinsUK , King's College London, London, England, United Kingdom
Sarah E. Berry, RD
– Senior Lecturer, King's College London, London, England, United Kingdom

Disclosure(s):

Kate M. Bermingham, Phd: No relevant financial relationship(s) with ineligible companies to disclose.

Objectives: The menopause transition is associated with unfavourable alterations in metabolic and cardiovascular health. However, as an age-related biological event, it is difficult to untangle effects of age from menopause. Here, we investigate the impact of menopause on cardiometabolic health, lifestyle and diet in pre- and post-menopausal females and age-matched subgroups (including males) in the densely phenotyped ZOE PREDICT 1 cohort (NCT03479866).

Methods: Demographic information, diet, cardiometabolic blood biomarkers and postprandial responses (lipid and glucose) to standardized test meals in clinic and free-living settings were assessed (n=1002). Self-reported pre- (n=366), peri- (n=55) and post-menopausal (n=207) females (aged 18-65y) and an age-matched subgroup (aged 47-56y) of males (n=76), pre- (n=83) and post-menopausal females (n=64) were identified. Linear regression analysis assessed differences in cardiometabolic health, anthropometry, lifestyle and diet (adjusted for sex, age, BMI, menopausal hormonal treatment and smoking status).

Results: Post-menopausal females had poorer fasting and postprandial blood measures (glucose, HbA1c, inflammation (GlycA), glucose_2hiauc and insulin_2hiauc; by 6, 5, 4, 42 and 4% respectively) and sleep quality (12%) and higher sugar intakes (12%) compared with pre-menopausal females (p < 0·05 for all). In age-matched females, postprandial glycemia was significantly higher in post- versus pre-menopausal females (p < 0·05), including clinic postprandial glucose peak0-2h (7·6±1·2 vs 7·2±1·0), glycemic variability (using a continuous glucose monitor (CGM)) (18±4 % vs 16±4 %) and glucose_2hiauc (CGM) following a standardized (typical UK/US nutrient composition) meal (13440±5804 vs 12547±5488). Compared to age-matched males, females (pre- and post-menopausal) had lower systolic blood pressure and ASCVD 10y risk (p < 0.05) and post-menopausal females only had worse glycemic variability (p < 0·001).

Conclusions: In the largest, in-depth nutrition metabolic study of menopause to date, we demonstrate unfavourable links between menopause transition and postprandial glycemic responses, sleep and diet. This emphasises the value of incorporating menopause as a factor in the delivery of nutrition advice.

Funding Sources: ZOE Ltd