(PO08-43-22) Association of Diet Quality Measured by Three A Priori-Defined Dietary Patterns With Gut Microbiota and Intestinal Permeability Among Obese Individuals

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Presenting Author(s)

SE

Sarah Eaton, BS
– Graduate student , University of Nebraska-Lincoln

Co-Author(s)

HR

Heather E. Rasmussen, PhD, RDN
– Associate Professor, University of Nebraska–Lincoln, Lincoln, Nebraska, United States
WC

Weiwen Chai, PhD
– Associate Professor, University of Nebraska-Lincoln, Lincoln, Nebraska, United States

Disclosure(s):

Sarah Eaton, BS: No relevant financial relationship(s) with ineligible companies to disclose.

Objectives: The human gastrointestinal tract (GI) may play a critical role in the prevention of obesity and metabolic diseases. Considering the importance of a healthy diet for optimal health, this study examined associations of diet quality assessed by three a priori-defined dietary patterns (Healthy Eating Index 2010 [HEI-2010], Mediterranean Eating Pattern for Americans [MEPA], and Dietary Approaches to Stop Hypertension [DASH] with gut microbiota, short-chain fatty acids (SCFA) and intestinal permeability markers in adult obese participants.

Methods: Analyses utilized baseline data from 103 obese subjects (43.8±11.3 years, body mass index≥30 kg/m², 72.8% females, 64.1% blacks) who participated in a probiotic/prebiotic supplement trial. Diet was assessed using a validated food frequency questionnaire. Associations of diet quality with outcome measures were assessed using partial correlation coefficient adjusting for relevant covariates. General linear models (GLM) were applied to compare covariate-adjusted means of outcomes for tertiles of respective dietary patterns scores.

Results: Scores of HEI-2010 (r=0.25, P=0.02), MEPA (r=0.24, P=0.03) and DASH (r=0.28, P<em>P=0.008) were positively associated with Blautia abundance. HEI-2010 score was positively associated butyrate and propionate to total SCFA ratio (r=0.24, P=0.048). Intestinal permeability marker, urinary 24-hr sucralose levels were inversely associated with HEI-2010 (r=-0.30, P=0.009) and MEPA (r=-0.26, P=0.02) score. The results were similar when GLM models were performed. No significant associations were observed between scores of dietary patterns and measures of microbial diversity.

Conclusions: Blautia abundance and inversely associated with intestinal permeability markers such as urinary 24-h sucralose levels suggesting diet quality may have positive impact on the human GI community.

Funding Sources: No funding support