(PO16-32-22) Sleep Quality Relates to Metabolic Health in Second Trimester of Pregnancy

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Presenting Author(s)

LH

Lauren Hand, MS, RD
– Graduate Teaching Assistant, KU Medical Center, Kansas City, Kansas, United States

Co-Author(s)

HH

Holly Hull, PhD
– Associate Professor, KU Medical Center, Kansas City, Kansas, United States
CS

Catherine Siengsukon
– University of Kansas Medical Center
Amy Herman, MS, RD
– Graduate Research Assistant, KU Medical Center, Kansas City, Kansas, United States

Disclosure(s):

Lauren Hand, MS, RD: No relevant financial relationship(s) with ineligible companies to disclose.

Amy Herman, MS, RD: No relevant financial relationship(s) with ineligible companies to disclose.

Objectives: Examine the relationships between self-reported sleep quality parameters and markers of metabolic health during pregnancy.

Methods: Baseline data collected at 12-20 weeks gestation from pregnant women enrolled in a high-fiber RCT (SPROUT; NCT04868110) were analyzed. Exclusion criteria included any known metabolic disturbance (e.g., history of diabetes, preeclampsia, hypertension). At the visit, a fasted blood draw, height, and weight were performed. Self-reported pre-pregnancy weight was collected. Sleep quality was assessed using the global Pittsburg Sleep Quality Index score (PSQI; >5 indicates poorer overall sleep quality) and sleep efficiency from the PSQI (100-point scale, higher indicates better efficiency). Total cholesterol (TC), low-density lipoprotein (LDL-C), high-density lipoprotein (HDL-C), triglycerides (TG), serum glucose, serum insulin, and hemoglobin A1c were analyzed using standardized protocols. Pearson’s correlations, means, and standard deviations were performed.

Results: Thirty-three participants were included in the analyses. Participants had a pre-pregnancy BMI of 25.4±4.3 kg/m², PSQI of 4.61±2.4, and sleep efficiency of 89.8±10.7. Sleep efficiency was related to TC (r=-0.41, p=0.018) and LDL-C (r=-0.418, p=0.016); and PSQI was related to LDL-C (r=0.372, p=0.033). No relationships were found between sleep parameters and other lipid or glycemic markers.

Conclusions: In a group of low-risk pregnant women, lower sleep efficiency and overall sleep quality were related to higher levels of blood lipids.

Funding Sources: Internal funding received from School of Health Professions at presenting author's academic institution.