(PO04-69-22) Vitamin C and Copper Intake Associated With Cognitive Function in Older Adults

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Presenting Author(s)

BR

Bharathi Ramesh, MS Human Nutrition
– Graduate student, University of Delaware, Arlington Heights, Illinois, United States

Co-Author(s)

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Arlene Isseks
– University of Delaware
JM

Jonathan Martin
– University of Delaware
SM

Safiyah Mansoori, BS
– Graduate Student, University of Delaware, Newark, Delaware, United States
AB

Annie Browne
– University of Delaware
RS

Richard R. Suminski, PhD
– Associate Professor, University of Delaware, Newark, Delaware, United States
SC

Sheau C. Chai, PhD, RD
– University of Delaware, Newark, Delaware, United States

Disclosure(s):

Bharathi Ramesh, MS Human Nutrition: No relevant financial relationship(s) with ineligible companies to disclose.

Objectives: Oxidative stress has been linked to the development of depression and anxiety as well as cognitive decline in older adults. Vitamins and minerals that have antioxidant properties or serve as cofactors can improve the oxidant-antioxidant balance in the body and lead to a reduction in oxidative stress and inflammation. We aimed to study antioxidant and antioxidant cofactor intake from diet in the older population in relation to mental and cognitive health.

Methods: A cross-sectional study was conducted that included 181 men and women aged 60–80 years. Individuals diagnosed with dementia, Alzheimer’s, or other neurological disorders were excluded. Dietary information was obtained using a 3-day diet record and food frequency questionnaire. Mental and cognitive health were assessed using Geriatric Depression Scale, Geriatric Anxiety Inventory, Montreal Cognitive Assessment (MoCA), and Digit Span test. Partial Pearson Correlation analyses were performed using SPSS software.

Results: Our findings indicate that vitamin B1 [r = .18, p < .05], vitamin C [r = .24, p < .001], vitamin D [r = .15, p < .05], and zinc [r = .15, p < .05] were positively correlated with Total Digit Span score, after controlling for antioxidant supplementation and other covariates such as age, education, economic status, etc. However, after further controlling for daily caloric intake, only vitamin C remained significantly associated with Total Digit Span score [r = .18, p < .05], and copper was inversely associated with MoCA scores [r = -.18, p < .05]. No other associations were found between the other variables.

Conclusions: Our findings suggest that higher vitamin C and lower copper intake from foods, are associated with cognitive performance among older adults. Further studies are needed to better understand the role of vitamin C and copper intake in cognitive function of older adults.

Funding Sources: None