(PO01-05-22) Whey Protein Supplementation and Type 2 Diabetes Mellitus Risk Factors: A Scoping Review of Systematic Reviews and/or Meta–Analyses of Randomized Controlled Trials

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Presenting Author(s)

GC

Gavin Connolly, MA
– Doctoral Student, Purdue University, West Lafayette, Indiana, United States

Co-Author(s)

Yu Wang, BS
– PhD Candidate, Purdue University, Department of Nutrition Science, West Lafayette, Indiana, United States
Robert E. Bergia, III, M.S.
– Purdue University, West Lafayette, Indiana, United States
ED

Eric M. Davis
– Purdue University
AB

Adam W. Byers, BSc
– Purdue University, West Lafayette, Indiana, United States
JR

Jason B. Reed, PhD
– Purdue University, West Lafayette, Indiana, United States
Wayne W. Campbell, PhD
– Professor, Purdue University, Department of Nutrition Science, Center on Aging and the Life Course, West Lafayette, Indiana, United States

Disclosure(s):

Gavin Connolly, MA: No relevant financial relationship(s) with ineligible companies to disclose.

Yu Wang, BS: No relevant financial relationship(s) with ineligible companies to disclose.

Objectives: Emerging research on whey protein supplementation WPS suggests it may be a potential modifier of type 2 diabetes mellitus (T2DM) risk factors, including glycemic regulation. As systematic reviews and/or meta-analyses of RCTS are gaining importance in nutrition literature, we conducted a scoping review to systematically search and chronicle published systematic reviews and/or meta-analyses of RCTs pertinent to WPS and T2DM modifiable risk factors.

Methods: The protocol was conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for scoping reviews (PRISMA-ScR) guidelines. Potentially eligible articles were identified via a systematic search of five electronic health research databases (PubMed, Cochrane Library, CINAHL (EBSCO), Scopus, and SPORTDiscus). Included articles were assessed for quality using the AMSTAR-2 critical appraisal tool.

Results: Eight of the 1,692 identified articles met the inclusion criteria. Of the 8 included articles, the outcomes related to T2DM risk factors reported in articles were as follows; 4 included HDL-cholesterol and triglycerides; 3 included fasting blood glucose, total cholesterol, LDL-cholesterol, and body weight; 1 included fasting insulin, HbA1c, blood pressures BMI, and CRP. The results of AMSTAR 2 critical appraisal tool showed that of the 8 included articles, 5 were deemed high quality, 2 were deemed moderate quality, and 1 article was deemed low quality.

Conclusions: Results of the scoping review identified no published systematic reviews and/or meta-analyses of RCTs that provide a comprehensive assessment specifically pertaining to the effects of WPS on T2DM modifiable risk factors. Future systematic reviews and/or meta-analyses of RCTs specifically investigating the effects of WPS on modifiable T2DM risk factors in a comprehensive manner are warranted.

Funding Sources: The Whey Protein Research Consortium