Award Lecture:Pharmacokinetics and Anti-Tumor Efficacy Effect of Nilotinib on Paclitaxel-Induced Peripheral Ceuropathy
This study tests the hypothesis that targeted inhibition of OATP1B2 function with nilotinib will specifically affect accumulation of paclitaxel in peripheral nerves and affect its downstream toxic effects without diminishing anticancer efficacy. The proposed work combines biochemical and physiological assessment of OATP1B using a continuous interplay between in vitro and in vivo experimental approaches, determines the direct contribution of OATP1B-type transporters to paclitaxel-related anticancer efficacy, as well as drug disposition properties and drug-drug interaction potential of the proposed intervention, provides the foundation for studies in the future aimed at ameliorating this agent’s debilitating neurological side effect in routine clinical practice.
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