P-010 - DEVELOPMENT OF A KINETIC-PHARMACODYNAMIC MODEL TO GUIDE FIRST IN HUMAN DOSE SELECTION FOR mRNA-6231, AN INVESTIGATIONAL mRNA THERAPEUTIC ENCODING A LONG-ACTING SELECTIVE IL-2 TO PREFERENTIALLY EXPAND REGULATORY T CELLS.
H. Attarwala1, I. Rajlic1, S. Picciotto1, D. Burdette1, B. Guglieri-Lopez2, V. Ivaturi2, B. Wipke1, S. Mori1, C. Lukacs1, J. Senn1; 1Moderna, Cambridge, MA, USA, 2Pumas.ai, Baltimore, MD, USA.