(10) Comparison of coronally advanced flap and connective tissue graft with or without enamel matrix derivative for gingival recession treatment: a systematic review and meta-analysis of randomized trials.

Introduction: The aim of this systematic review and meta-analysis was to assess whether the addition of enamel matrix derivative (EMD) to a coronally advanced flap (CAF) combined with a connective tissue graft (CTG) resulted in a greater amount of root coverage in patients treated for gingival recessions, compared to CAF+CTG alone.

Methods: The search for clinical trials on root coverage procedures comparing CAF+CTG+EDM versus CAF+CTG was completed on online databases and gray literature, including studies published up to January 2022. The risk of bias was assessed using the Cochrane bias assessment tool and the quantitative analysis was performed using a random effects model.

Results: A total of 1917 articles were identified and 12 underwent full-text review. Three studies were excluded and 9 were selected for full analysis. The meta-analysis showed that there is a statistically significant difference (mean difference: 0.3 mm, 95% CI: 0.01-0.58 mm, p=0.04) in favor of the CAF+CTG+EMD group compared to CAF+CTG alone for the amount of root coverage, measured in millimeters.

Conclusions: According to the results of this systematic review and meta-analysis, the addition of EMD to CAF+CTG results in a greater amount of root coverage in teeth treated for gingival recessions.

Lead Author’s Contributions to the Research Project: The Lead Author was responsible for the study design, contributed to the data collection, data analysis and composed the abstract.