Background and objective: A bidirectional relationship between diabetes and periodontitis and a higher incidence of liver disease in periodontitis patients have been shown. The proportion of patients with diabetes who progress from nonalcoholic fatty liver disease to liver cancer was twice as high as that of healthy individuals. However, there are still few reports that comprehensively analyzed the relationship between diabetes, liver function, and periodontal disease. The purpose of this study was to clarify the relationship of those diseases, focusing on diabetes index (HbA1c), periodontal index (PISA), and liver function markers. Materials and
Methods: Subjects were recruited from 2018 to 2021 at the Medical and Dental Collaboration Centre, Kanagawa Dental University Hospital. HbA1c was measured to assess diabetes. PISA was calculated from periodontal clinical examination. AST, ALT and γ-GTP were measured as liver function markers. The correlation between diabetes, periodontal disease and liver function markers was examined. The study was approved by the Kanagawa Dental University Ethical Review Committee (No. 553).
Results: A total of 277 subjects (182 women and 95 men) with a mean age of 67 years were included in the study. Higher proportion of high PISA patients was found in the high HbA1c group compared to the low HbA1c group. Only AST was an increased marker among liver function indicators in the high HbA1c group. AST and γ-GTP were also increased in the high PISA group.
Conclusion: The results of the present study confirmed the association between diabetes and periodontitis and showed their association with liver function.
