OT07 - Hepatic Dearterialization in Dogs and Cats with Massive or Diffuse Liver Tumor

Abstract:  Transarterial coil embolization of the hepatic artery may provide a palliative option for non-resectable massive or diffuse liver tumors in dogs and cats.

Hypothesis: Hepatic dearterialization is a safe palliative management option in dogs/cats with liver tumors.

Animals: Four dogs and two cats with massive or diffuse liver masses evaluated at the Animal Medical Center (AMC).

Methods: A retrospective review of patients who underwent transarterial coil embolization of the hepatic artery from the origin of the gastroduodenal artery to the proximal hepatic artery. Medical records were reviewed for patient signalment, clinical signs, biochemical changes, cross sectional imaging, complications, and response to treatment. Bloodwork and tumor dimensions were recorded prior to, and approximately six weeks following hepatic dearterialization.

Results: All six patients survived to discharge and four (4/6) were discharged 24 hours after treatment. Two (2/6) patients experienced mild short-term vomiting and anorexia, one of whom required repeat hospitalization. Elevated pre-treatment hepatocellular enzymes exponentially increased 24 hours post-operatively in all patients. Repeat bloodwork analysis ~6 weeks after treatment demonstrated improved ALT and AST in 4/5 patients evaluated and improved ALP in 3/5 patients when compared to pre-treatment levels. Repeat imaging performed and post-mortem results demonstrated tumor regression in 4/4 patients evaluated. Overall survival times ranged from 60 - 505 days (MST 197.4 days).

Conclusion: Hepatic dearterialization was performed successfully in all six patients with limited reported side effects. Tumor regression and improved hepatocellular enzymes were appreciated in most patients approximately 6 weeks after treatment.