OT10 - The PETSORT Statement: Reporting Guidelines for Randomized Controlled Trials Conducted in Dogs and Cats

Abstract: Background

Comprehensive reporting of randomized clinical trials (RCTs) is essential for the reader to evaluate the methodological rigor of the trial and interpret the generalizability. However, a recent study evaluating comprehensive reporting of published RCTs using dogs and cats found that there were significant deficiencies in reporting trial methods and other information crucial for interpretation of trial results. The Consolidated Standards of Reporting Trials (CONSORT) statement is used to improve reporting of published RCTs conducted in human populations.



Objectives

To create standardized guidelines based on the CONSORT statement to aid researchers in reporting RCTs conducted using dogs and cats.



Animals

None.



Methods

A consensus group of 52 experts in clinical trial design, biostatistics, epidemiology, and subject matter specialists worked together to modify the CONSORT (Consolidated Standards of Reporting Trials) statement to reflect the unique aspects of reporting RCTs conducted in small animals.



Results

The consensus group work resulted in the production of the PETSORT statement for reporting RCTs in dogs and cats and a 25-item checklist that authors can use to ensure complete reporting.



Conclusions and clinical importance

The use of the PETSORT statement, which addresses issues unique to companion animal trials, when designing and publishing RCTs should improve the quality of study design and reporting for trials conducted in dogs and cats.