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Scientific Session

Small Animal Internal Medicine

Mechanisms of NSAID-Induced GI Injury in Dogs

On Demand

CE: 1

Primary Presenter(s)

Kristen Messenger, kmmessen@ncsu.edu

Associate Professor of Clinical Pharmacology
North Carolina State University College of Veterinary Medicine
Raleigh, North Carolina, United States

Slides

Gastrointestinal side effects are the most common side effects of all NSAIDs in dogs, and can range from mild to life-threatening. This presentation will review the clinical pharmacology of NSAIDs, discuss in detail different mechanisms of injury in different portions of the gastrointestinal tract, and compare what is known regarding mechanisms of injury in dogs to other species. It will also present evidence for and against different therapeutics for the prevention and treatment of NSAID induced injury.

Learning Objectives:

Upon completion, participant will be able to list and describe mechanisms of NSAID-induced injury to different anatomic regions of the GI tract.
Upon completion, participant will be able to explain the evidence against using prophylactic proton pump inhibitors to prevent GI injury in dogs.
Upon completion, participant will be able to discuss the evidence available for alternative modulators of inflammation to either treat pain or manage NSAID-induced GI injury in dogs.