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Professor
Washington University School of Medicine
St. Louis, Missouri, United States
BIOGRAPHICAL SKETCH
NAME: Opeolu M. Adeoye, MD, MS
eRA COMMONS USER NAME: ADEOYEOM
POSITION TITLE: BJC HealthCare Professor and Chair, Department of Emergency Medicine, Washington University School of Medicine, St. Louis, MO
EDUCATION/TRAINING:
INSTITUTION AND LOCATION DEGREE Completion Date FIELD OF STUDY
University of Maryland Baltimore County (UMBC), MD BA, BS 06/1998 Philosophy, Biochemistry
University of Pittsburgh, Pittsburgh, PA MD 06/2002 Medicine
University of Cincinnati, Cincinnati, OH Residency 06/2006 Emergency Medicine
University of Cincinnati, Cincinnati, OH Fellowship 06/2008 Neurovascular Emergencies and Neurocritical Care
University of Cincinnati, Cincinnati, OH MS 06/2012 Clinical and Translational Research
A. Personal Statement
I have extensive clinical trial experience. I am Lead and Administrative PI of the Phase 3 Multi-arm Optimization of Stroke Thrombolysis (MOST) Trial that is the collaborative culmination of the CLEAR Trials, for which I was also PI. I serve as Multiple PI of the University of Cincinnati Hub Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN), previously serving as Contact PI prior to my recent move to Washington University in Saint Louis.
My primary area of clinical research interest is in developing and testing novel antithrombotic approaches to the treatment of acute ischemic stroke. I previously conducted Phase 2 clinical trials (the CLEAR trials) testing eptifibatide, a glycoprotein 2b/3a inhibitor, as an adjunct to thrombolysis in ischemic stroke. That work led to the ongoing Phase 3 MOST trial. This interest has also led to my conducting translational research using high throughput “omics” techniques to pursue diagnostic and prognostic markers for both ischemic and hemorrhagic stroke. In the near term, I hope to expound on this work to identify pathways that may contribute to stroke outcomes and response to treatment in order to develop new treatments for stroke.
Publications and Research Products
a. Deeds SI, Barreto A, Elm J, Derdeyn CP, Berry S, Khatri P, Moy C, Janis S, Broderick J, Grotta J, Adeoye O. The multiarm optimization of stroke thrombolysis phase 3 acute stroke randomized clinical trial: Rationale and methods. Int J Stroke. 2021 Oct;16(7):873-880. PMID: 33297893
b. Dickert NW, Scicluna VM, Adeoye O, Angiolillo DJ, Blankenship JC, Devireddy CM, Frankel MR, Goldkind SF, Kumar G, Ko YA, Mitchell AR, Nogueria RG, Parker RM, Patel MR, Riedford M, Silbergleit R, Speight CD, Spokoyny I, Weinfurt KP, Pentz RD. Emergency Consent: Patients' and Surrogates' Perspectives on Consent for Clinical Trials in Acute Stroke and Myocardial Infarction. J Am Heart Assoc. 2019 Jan 22;8(2):e010905. PMID: 30663498
c. Broderick JP, Adeoye O, Elm J. Evolution of the Modified Rankin Scale and Its Use in Future Stroke Trials. Stroke. 2017 Jul;48(7):2007-2012. PMID: 28626052
Ongoing and recently completed projects that I would like to highlight include:
NIH / PAR-14-220 PI: O. Adeoye 09/01/2017–08/31/2023
Multi-arm Optimization of Stroke Thrombolysis (MOST) Stroke Trial
The University of Cincinnati (UC) Hub and The MOST trial will test whether rt-PA combined with one or the other
Role: PI
NIH / RFA-NS-16-016 PI: O. Adeoye 02/01/2017–01/31/2022
Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN)
Role: PI
Making a Difference Program (Greenwall Foundation) PI: N. Dickert 01/2018-12/20
The MOST-consent study: Patient-driven consent for a multi-center adaptive trial in acute ischemic stroke.
Role: Co-Investigator
NIH-NINDS / U01 NS086090 PI: G. Manley 09/01/2013–08/31/2018
Transforming Research and Clinical Knowledge in Traumatic Brain Injury II (TRACK-TBI II)
Role: Site PI
NIH-NINDS / U01 NS088312 PI: P. Lyden 07/01/2014–06/30/2018
Safety Evaluation of 3K3A-APC in Ischemic Stroke (NN104)
Role: Co-Investigator
NIH-NINDS / U01 NS058982 PI: O. Adeoye 09/01/2006–07/31/2017
The Greater Cincinnati/Northern Kentucky NETT Network Hub and Spoke System
Role: PI
B. Positions, Scientific Appointments, and Honors
Positions and Employment
2021-Present BJC HealthCare Professor and Chair, Department of Emergency Medicine, Washington University School of Medicine, St. Louis, MO
2020-2021 Professor, Departments of Emergency Medicine and Neurosurgery, University of Cincinnati, Cincinnati, OH
2013-2020 Associate Professor, Departments of Emergency Medicine and Neurosurgery, University of Cincinnati, Cincinnati, OH
2010-2013 Assistant Professor, Departments of Emergency Medicine and Neurosurgery, University of Cincinnati, Cincinnati, OH
2009-2010 Instructor, Departments of Emergency Medicine and Neurosurgery, University of Cincinnati, Cincinnati, OH
2006-2008 Neurovascular Emergencies / Neurocritical Care Fellow, University of Cincinnati, Cincinnati, OH
2002-2006 Resident in Emergency Medicine, University of Cincinnati, Cincinnati, OH
1996-1998 Tutor, Department of Philosophy UMBC, Baltimore, MD
1995-1998 Research Technician, Department of Biology UMBC, Baltimore, MD
Other Experience and Professional Memberships
2002-Present American College of Emergency Physicians, Member
2006-Present Society for Academic Emergency Medicine, Member
2006-Present American Heart Association, Member
2006-Present Society of Critical Care Medicine, Member
2006-Present Neurocritical Care Society, Member
2011-2018 Medical Director for Telestroke, UC Health University Hospital
2012-2013 Interim Director, Division of Neurocritical Care, University of Cincinnati
2012-2013 Co-Medical Director, Neuroscience Intensive Care Unit, UC Health University Hospital
2015-2020 Co-Director, University of Cincinnati Stroke Team
Honors
1998 Phi Beta Kappa UMBC, Baltimore, MD
2000 AAMC Herbert W. Nickens Scholar
2001 Albert Schweitzer Fellow
2002 Area of Concentration in Underserved Medicine, University of Pittsburgh, Pittsburgh, PA
2007 Top Three Cases Award, Neurocritical Care Society Annual Meeting, New Orleans, LA
2008 Hero Award, University Hospital, Cincinnati, OH
2008-2010 Next Generation Biomedical Investigator, Center for Environmental Genetics, University of Cincinnati, Cincinnati, OH
2017 Innovator, Cincinnati Business Courier, Cincinnati, OH
C. Contributions to Science.
1. Societal burden of stroke and impact of interventions. My early publications reflect my desire to quantify the extent of the societal burden of stroke and the potential impact of various interventions on this burden. I was fortunate to have mentors involved in stroke epidemiology research. As such, I sought to derive evidence for the extent of the stroke burden and the dent that given interventions may make in that burden. By fully understanding the epidemiology of stroke, realistic clinical trials may be designed that target subpopulations of stroke patients. My initial focus was acute intracerebral hemorrhage and blood pressure management in ischemic and hemorrhagic stroke:
a. Flaherty ML, Adeoye O, Sekar P, et al. The Challenge of Designing a Treatment Trial for Warfarin-Associated Intracerebral Hemorrhage. Stroke. 2009 May;40(5):1738-42. PMCID: PMC2674527.
b. Adeoye O, Woo D, Haverbusch M, et al. Surgical Management and Case Fatality Rates of Intracerebral Hemorrhage in 1988 and 2005. Neurosurgery. 2008;63:1113-7. PMCID: PMC2717618.
c. Adeoye O, Woo D, Haverbusch M, et al. Eligibility For The Surgical Trial In Intracerebral Hemorrhage II Study In A Population-Based Cohort. Neurocrit Care. 2008;9:237-41. PMCID: PMC2672191.
d. Jauch EC, Lindsell CJ, Adeoye O, et al. Lack of Evidence For An Association Between Hemodynamic Variables And Hematoma Growth In Spontaneous Intracerebral Hemorrhage. Stroke 2006;37:2061-5. PMID: 16794216.
2. Neurological Emergency Treatment. Throughout my career, I have actively participated in the design, conduct and publication of clinical trials in neurological emergencies including stroke, seizures and traumatic brain injury. I currently serve as Site PI and Steering Committee member on the Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) observational study designed to fully characterize the population of patients with traumatic brain injury (TBI). I also serve as PI of the University of Cincinnati Hub of the Neurological Emergencies Treatment Trials (NETT) Network, a clinical research infrastructure designed to facilitate patient enrollment in acute neurological emergencies clinical trials. Lastly, I served as PI of the Combined approach to Lysis utilizing Eptifibatide And Recombinant tissue plasminogen activator in acute ischemic stroke-Enhanced Regimen (CLEAR-ER), and PI of the recently completed CLEAR-Full Dose Regimen (CLEAR-FDR) clinical trials. The CLEAR trials are the pilot work for the ongoing MOST trial.
Selected publications on access to care, clinical trial results and device development for stroke triage are listed below:
a. Kandadai MA, Korfhagen JJ, Beiler S, Beiler C, Wagner K, Adeoye OM, Shaw GJ. In vivo testing of a non-invasive prototype device for the continuous monitoring of intracerebral hemorrhage. J Neurosci Methods. 2014 Sep 30;235:117-22. PMID: 24997340
b. Adeoye O, Albright KC, Carr BG, Wolff C, Mullen MT, Abruzzo T, Ringer A, Khatri P, Branas C, Kleindorfer D. Geographic access to acute stroke care in the United States. Stroke. 2014;45(10):3019-24. PMID: 25158773.
c. Kleindorfer D, de Los Rios La Rosa F, Khatri P, Kissela B, Mackey J, Adeoye O. Temporal trends in acute stroke management. Stroke. 2013 Jun;44(6 Suppl 1):S129-31. PMID: 23709709.
d. Pancioli AM, Adeoye O, Schmit PA, Khoury J, Levine SR, Tomsick TA, Sucharew H, Brooks CE, Crocco TJ, Gutmann L, Hemmen TM, Kasner SE, Kleindorfer D, Knight WA, Martini S, McKinney JS, Meurer WJ, Meyer BC, Schneider A, Scott PA, Starkman S, Warach S, Broderick JP. The Combined Approach to Lysis Utilizing Eptifibatide and rt-PA in Acute Ischemic Stroke - Enhanced Regimen (CLEAR-ER) Stroke Trial. Stroke. 2013 Sep;44(9):2381-7. PMCID: PMC3970761.
3. Translational Stroke Research. In addition to the epidemiologic burden and emergency treatment of stroke, I have a keen and longstanding interest in conducting focused translational research that advance pathophysiologic understanding of stroke. With improved mechanistic understanding of stroke biology, novel treatments may be developed for stroke prevention, treatment and recovery. Selected publications in this area include:
a. Walsh KB, Zhang X, Zhu X, Wohleb E, Woo D, Lu L, Adeoye O. Intracerebral hemorrhage induces monocyte-related gene expression within six hours: Global transcriptional profiling in swine ICH. Metab Brain Dis. 2019 Jun;34(3):763-774. PMID: 30796715
b. Walsh KB, Sekar P, Langefeld CD, Moomaw CJ, Elkind MS, Boehme AK, James ML, Osborne J, Sheth KN, Woo D, Adeoye O. Monocyte Count and 30-Day Case Fatality in Intracerebral Hemorrhage. Stroke. 2015 Aug;46(8):2302-4. PMID: 26130090
c. Kodali P, Chitta KR, Landero Figueroa JA, Caruso JA, Adeoye O. Detection of metals and metalloproteins in the plasma of stroke patients by mass spectrometry methods. Metallomics. 2012 Oct;4(10):1077-87. PMID: 22983496
d. Kodali P, Jurkevica A, Landero J, Kuhlmann C, Caruso J, Adeoye O. Multiple liquid chromatography separations and nanoESI-ion trap detection of plasma proteins in search of stroke biomarkers: A pilot study. J Sep Sci. 2012 Sep;35(17):2153-61. PMID: 22807420
Complete List of Published Work in MyBibliography:
https://www.ncbi.nlm.nih.gov/myncbi/1xmd0OqYRzvkZ/bibliography/public/
Sense Diagnostics, Inc. (Products/Services: No) (Ownership Interest)
Thursday, November 10, 2022
3:55 PM – 4:11 PM
