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Associate Professor
University of Virginia
I do not have any relevant financial / non-financial relationships with any proprietary interests.
BIOGRAPHICAL SKETCH
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NAME: Chapman, Sherita Nicole
eRA COMMONS USER NAME (credential, e.g., agency login): SC2BDNIH
POSITION TITLE: Assistant Professor of Neurology, Co-Chair of Comprehensive Stroke Center at University of Virginia Health System
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable. Add/delete rows as necessary.)
INSTITUTION AND LOCATION DEGREE
(if applicable)
Completion Date
MM/YYYY
FIELD OF STUDY
Virginia Union University B.S 05/2002 Biology
Howard University College of Medicine M.D. 06/2008 Medicine
Howard University Hospital Internship 06/2009 Internal Medicine
Howard University Hospital Residency 06/2012 Neurology
University of Virginia Fellowship 06/2014 Vascular Neurology
A. Personal Statement
As a vascular neurologist with experience in telemedicine and previous training as an EMT I have the expertise and training to carry out the proposed research project. My previous EMT training and strong established relationship with the Ambulance Authorities provide me with both insight and collaborative experiences to conduct effective research in the prehospital setting. I have laid the groundwork for this research project by demonstrating the feasibility of mobile telestroke in a simulated setting. This was conducted in conjunction with the Richmond Ambulance Authority (RAA) and my Dr. Joseph Ornato (RAA medical director). Dr. has extensive expertise in prehospital research and community engagement. Through my previous prehospital research, I have gained a deep understanding of the challenges of collaboration of multiple stakeholders and organizations involved. I also understand the importance of communication, realistic expectations in the prehospital setting and time management. To gain a deeper understanding of the challenges acute stroke health care providers face on the island of O’ahu with implementing an ambulance based telestroke program I have worked with focus groups and conducted informal interviews. The key findings of this exercise were the need to include durable, user friendly equipment, establishing a statewide program and the need to have thoughtful integration of processes and protocols. We were also cautioned about possible unintended consequences of the program such as liability risks, increased workflow, a lack of manpower and reliance on technology that might not perform.
1. Chapman Smith SN, Brown PC, Waits KH, Wong JS, Bhatti MS, Toqeer Q, Ricks JV, Stockner ML, Habtamu T, Seelam J, Britt RC, Giovia JM, Blankson BK, Bennam P, Gormley MA, Lu J, Ornato JP. Development and Evaluation of a User-Centered Mobile Telestroke Platform. Journal of Telemedicine and e-Health. 2018 https://doi.org/10.1089/tmj.2018.0044. Cited 2 times, IF = 2.165
2. Sherita N. Chapman Smith, MD*, Prasanthi Govindarajan, MD, MAS*, Matthew M. Padrick, MD, Jason M. Lippman, BA, Timothy L. McMurry, PhD, Brian L. Resler, MD, Kevin Keenan, MD, Brian S. Gunnell, BA, Prachi Mehndiratta, MD, Christina Y. Chee, MD, Elizabeth A. Cahill, MD, Cameron Dietiker, MD, David C. Cattell-Gordon, MDiv, MSW, Wade S. Smith, MD, PhD, Debra G. Perina, MD, Nina J. Solenski, MD, Bradford B. Worrall, MD, MSc, Andrew M. Southerland, MD, MSc; As the iTREAT Investigators. A low-cost, tablet-based option for prehospital neurologic assessment. Neurology 2016; 87:19–26.
3. Lippman JM, Chapman Smith SN, McMurry TL, Sutton ZG, Gunnell BS, Cote J, Perina DG, Cattell-Gordon DC, Rheuban KS, Solenski NJ, Worrall BB, Southerland AM. Mobile Telestroke During Ambulance Transport Is Feasible in a Rural EMS Setting: The iTREAT Study. Telemed J E Health. 2015 Nov 24.
4. Pitchford H, Divers M, Chapman S, Southerland A. Prehospital Telemedicine and EMS Integration. Telemedicine in the ICU. Springer Nature, pp 281 – 305. Doi: 10.1007/978-3-030-11569-2.
B. Positions and Honors
Positions and Employment
2020 – Co-director of the Comprehensive Stroke Center (CSC), University of Virginia, Charlottesville, VA
2018 – Associate-director of the UVA Telestroke Program, University of Virginia, Charlottesville, VA
2018 – Affiliate Assistant Professor, Department of Neurology, Virginia Commonwealth University, Richmond, VA
2018 – Assistant Professor, Department of Neurology, University of Virginia, Charlottesville, VA
2014- 2018 Assistant Professor, Department of Neurology, Virginia Commonwealth University, Richmond, VA
2014-2016 Visiting Assistant Professor, Department of Neurology, University of Virginia, Charlottesville, VA
2013-2014 Clinical Instructor, Department of Neurology, University of Virginia, Charlottesville, VA
Certification and Licensure
General Adult Neurology, ABPN Certified September 2013, #58036
Vascular Neurology, ABPN Certified August 2014. #1325
Virginia State License, June 2012. #0101252190
Other Experience and Professional Memberships
2019 – Member, World Stroke Organization
2018 – Member, National Medical Association (NMA)
2018 - Co-Chair, Virginia Stroke Systems Task Force
2015 - Member, American Neurological Association
2014 - Reviewer, American Academy of Neurology Annual Conference Abstract
2013 - Reviewer, Neurology Journal
2013 - 2014 Certified Adjudicator, Phenotype Core, NINDS Ischemic Stroke Genetic Consortium
2013 - Member, Virginia Stroke TeleHealth Network
2012 - Member, American Heart Association/American Stroke Association
2008 - Member, American Academy of Neurology
Honors
2017-2019 NIH Loan Repayment Program Award
2016-2018 Virginia Commonwealth University (VCU) Center for Clinical and Translational Research (CCTR) Emerging Scholar Program (ESP) Scholar
2016-2017 NHLBI Program to Increase Individuals Engaged in Health-Related Research (PRIDE) UCSF Research in Implementation Science for Equity (RISE) Scholar
2014-2015 Virginia Commonwealth University (VCU) Department of Neurology Faculty Outstanding Teaching Award
2011 American Academy of Neurology (AAN) Palatucci Advocate
2004 VCU CCTR Emerging Scholar
2003 Research in Implementation Science for Equity (RISE) Scholar
C. Contribution to Science
1. During the course of my fellowship training, I had the wonderful opportunity to participate as a certified adjudicator within the Phenotype Core Group of the NINDS Ischemic Stroke Genetic (SiGN) Consortium. In addition, I helped develop and validated a method of using clinical trial data from large multicenter trials to generate stroke phenotypes. My contribution in stroke genetics helped provide knowledge related to developing a systematic way to determining stroke phenotypes in large multicenter studies. I served as co-investigator in all of these studies.
a. NINDS Stroke Genetics Network (SiGN) and International Stroke Genetics Consortium. Loci associated with ischaemic stroke and its subtypes (SiGN): a genome-wide association study. Lancet Neurol 2015; published online Dec 18.
b. Ay H, Arsava EM, Andsberg G, Benner T, Brown RD, Chapman SN, Cole JW, Delavaran H, Dichgans M, Engström G, Giralt-Steinhauer E, Grewal RP, Gwinn K, Jern C, Jimenez-Conde J, Jood K, Katsnelson M, Kissela B, Kittner SJ, Kleindorfer DO, Labovitz DL, Lanfranconi S, Lee JM, Lehm M, Lemmens R, Levi C, Li L, Lindgren A, Markus HS, McArdle PF, Melander O, Norrving B, Peddareddygari LR, Pedersén A, Pera J, Rannikmäe K, Rexrode KM, Rhodes D, Rich SS, Roquer J, Rosand J, Rothwell PM, Rundek T, Sacco RL, Schmidt R, Schürks M, Seiler S, Sharma P, Slowik A, Sudlow C, Thijs V, Woodfield R, Worrall BB, Meschia JF. Pathogenic ischemic stroke phenotypes in the NINDS-stroke genetics network. Stroke.2014 Dec;45(12):3589-96.
c. Chapman Smith S, McClure LA, Gamble D, Benavente OR, Brown, Jr. RD, Kittner SJ, Ay H, Meschia JF, Worrall BB. Using clinical trial data to generate Causative Classification System (CCS) ischemic stroke phenotypes for the NINDS Stroke Genetics Network (SiGN). International Stroke Conference, Nashville, TN, February 2015.
2. In addition to the contributions described above, with a team of collaborators, I have helped provide detailed systematic reviews in the field of acute stroke care and effective work-up strategies for stroke. This body of work also discusses the importance of tPA in acute stroke care and useful tips to work-up stroke patients to determine etiology.
a. Mehndiratta P, Chapman Smith S, Worrall BB. Etiologic stroke subtypes: updated definition and efficient workup strategies. Curr Treat Options Cardiovasc Med 2015 Jan;17(1):357.
b. Chapman SN, Mehndiratta P, Johansen MC, McMurry TL, Johnston KC, Southerland AM. Current perspectives on the use of intravenous recombinant tissue plasminogen activator (tPA) for treatment of acute ischemic stroke. Vascular Health and Risk Management. Vol. 2014:10, pages 75-87.
Complete List of Published Work in MyBibliography: https://www.ncbi.nlm.nih.gov/sites/myncbi/1zqvafrMjfbQ3/bibliography/51032910/public/?sort=date&direction=ascending.
D. Additional Information: Research Support and/or Scholastic Performance
Clinical Trials: Active
Site Principal Investigator, Multi-arm Optimization of Stroke thrombolysis (MOST) Stroke Trial. Three-arm, adaptive Phase 3, blinded, randomized controlled clinical study evaluating the augmentation of IV tPA thrombolysis with either direct thrombin inhibition or inhibition of the GP 2b/3a receptor.
2018 to present.
Sub-Investigator, ARCADIA, Atrial Cardiopathy and Antithrombotic Drugs In Prevention After Cryptogenic Stroke. Multicenter, biomarker-drive, randomized, double-blind, active control, phase 3 clinical trial to apixaban versus aspirin in patients who have evidence of atrial cardiopathy and a recent stroke of unknown cause. 2018 to present.
Sub-Investigator, SleepSMART, Sleep for Stroke Management and Recovery Trial. Multicenter, prospective, randomized, open-label, blinded-endpoint, parallel-group superiority trial that compares 6 months of OSA treatment to usual care. 2019 to present.
Sub-Investigator. PHAST-TSC. Efficacy and Safety of Trans Sodium Crocetinate (TSC) for Treatment of Suspected Stroke. Multicenter, randomized, placebo-controlled, double blind, parallel group trial of intravenous trans sodium crocetinate (TSC) initiated by emergency medical service 9EMS) responders in the field within 2 hours of symptom onset. 2019 to present.
Sub-Investigator, TIMELESS, Tenecteplase in Stroke Patients between 4 and 24 Hours. Phase III, prospective, double-blind, randomized, placebo-controlled trial of thrombolysis in imaging-eligible, late-window patients to assess the efficacy and safety of tenecteplase. 2019 to present.
Sub-Investigator, GEMSTONE, A Study of the Relationship of Gut Microbial Composition and Stroke Outcomes. Observational, prospective study to measure differences in taxonomic make-up and relative frequency of the guy microbial composition in relation to stroke outcome. 2018 to present.
Sub-Investigator, STRONG, The Stroke, Stress, Rehabilitation, and Genetics Study. Study to examine how stress and genetics can affect rehabilitation after stroke. 2018 to present.
Completed Research Support
VCU Dean’s Enhancement Award Chapman (PI) 04/01/16-07/31/16
Pre-hospital Rapid Evaluation via Ambulance Lead Emergency Remote Telemedicine (PREALERT)
The major goal of this project are to evaluate the feasibility and reliability of a mobile prehospital telestroke system in a clinical simulated setting.
Role: PI
UL1TR000058 CCTR Endowment Award Chapman (PI) 01/08/16-07/31/17
The major goals of this project are to (1) evaluate the feasibility and reliability of a mobile prehospital telestroke system in a clinical simulated setting and (2) obtain preliminary data related to feasibility in live stroke patients. Role: Co-Investigator
