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Professor and Chairman
Toho University Faculty of Medicine
I do not have any relevant financial / non-financial relationships with any proprietary interests.
Osamu Kano, M.D., Ph.D.
(former family name: Igarashi)
Professor and Chairman
Department of Neurology
Toho University Faculty of Medicine
6-11-1 Omorinishi Ota-ku
Tokyo 143-8541 Japan
Phone: +81-3-3762-4151
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Education
1993-1998 M.D. in Faculty of Medicine
Toho University, Tokyo, Japan
2001-2004 Ph.D. in Department of Neurology
Graduate School of Medicine, Toho University, Tokyo, Japan
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Medical Training and Professional Experiences
1999-2000 Resident in Department of Neurology
Toho University Ohashi Medical Center, Tokyo, Japan
2002 Neuroradiology Resident in Department of Radiology
Juntendo University, Tokyo, Japan
Neuropathology Resident in Tokyo Metropolitan Institute for Neuroscience, Tokyo, Japan
Neurology Resident in National Center of Neurology and Psychiatry Musashi Hospital, Tokyo, Japan
2005 Resident in NTT East Corporation Kanto Medical Center, Tokyo, Japan
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Postgraduate Training
2007-2011 Postdoctoral Researcher
Weill Cornell Medical College, Methodist Neurological Institute, Houston, USA
Advisor: Dr. Stanley Appel
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Academic Appointments
2006, 2012-2018 Assistant Professor
Department of Neurology
Toho University Faculty of Medicine, Tokyo, Japan
2019–present Professor and Chairman
Toho University Faculty of Medicine, Tokyo, Japan
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Specialty Boards
Japanese Board of Internal Medicine (2005)
Japanese Board of Neurology (2006)
Japanese Board of Stroke (2012)
Japanese Board of Dementia (2015)
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Honors and Awards
Kanae Foundation for the Promotional of Medical Science (2007)
The Uehara Memorial Foundation (2008)
Highlighted poster (62nd Annual Meeting, American Academy of Neurology, 2010)
Takeshi Yanase Foundation (2011)
The Best Activity Award of Japanese Society of Neurological Therapeutics (2018)
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Publications
Igarashi O et al. Lateral lower medullary infarction. Arch Neurol 61:1609, 2004
Igarashi O et al. Cheiro-pedal syndrome following pontine infarction. Neurol Res 27:103-104, 2005
Igarashi O et al. Cheiro-oral-pedal syndrome due to brainstem hemorrhage. Clin Neurol Neurosurg 108:507-510, 2006
Kano O et al. Beneficial effect of pramipexole for motor function and depression in Parkinson’s disease. Neuropsychiatr Dis Treat 4:707-710, 2008
Kano O et al. Transient restricted diffusion of whole corpus callosum and symmetrical white matter in epilepsy. Intern Med 48:583-584, 2009
Kano O et al. Limbic encephalitis associated with systemic lupus erythematosus. Lupus 18:1316-1319, 2009
Kano O et al. Neurobiology of depression and anxiety in Parkinson’s disease. Parkinson’s disease 143547, 2011
Beers DR, Zhao W, Liao B, Kano O, Wang J, Huang A, Appel SH, Henkel JS: Neuroinflammation modulates distinct regional and temporal clinical responses in ALS mice. Brain Behav Immun 25:1025-1035, 2011
Kano O et al. Pramipexole protects spinal motor neuron death against glutamate-induced neurotoxicity. J Neurol Res 1:127-132, 2011
Kano O, Beers DR, Henkel JS, Appel SH：Peripheral nerve inflammation in ALS mice：cause or consequence. Neurology 78:833-835, 2012
Kano O et al. Limb-onset amyotrophic lateral sclerosis patients visiting orthopedist show a longer time-to-diagnosis since symptom onset. BMC Neurol 9;13-19, 2013
Kano O et al. Clinically meaningful treatment responses after switching to galantamine and with addition of memantine in patients with Alzheimer's disease receiving donepezil. Neuropsychiatr Dis Treat 9:259-265, 2013
Kano O et al. Domperidone effective in preventing rivastigmine-related gastrointestinal disturbances in patients with Alzheimer’s disease. Neuropsychiatr Dis Treat 9:1411-1415，2013
Kano O et al. Rhinorrhea in Parkinson's disease: A consecutive multicenter study in Japan. J Neurol Sci 343:88-90, 2014
Watanabe H, Atsuta N, Nakamura R, Hirakawa A, Watanabe H, Ito M, Senda J, Katsuno M, Izumi Y, Morita M, Tomiyama H, Taniguchi A, Aiba I, Abe K, Mizoguchi K, Oda M, Kano O, Okamoto K, Kuwabara S, Hasegawa K, Imai T, Aoki M, Tsuji S,Nakano I, Kaji R, Sobue G：Factors affecting longitudinal functional decline and survival in amyotrophic lateral sclerosis patients. Amyotroph Lateral Scler Frontotemporal Degener 16:230-236, 2015
Kawagoe N, Kano O (EQ) et al. Investigation of metabolism of exogenous glucose at the early stage and onset of diabetes mellitus in Otsuka Long-Evans Tokushima Fatty rats using [1, 2, 3-13C] glucose breath tests. PLoS One 11:e0160177, 2016
Yanagihashi M, Kano O(EQ) et al. Late-onset spinal form xanthomatosis without brain lesion: a case report. BMC Neurol 16:21, 2016
Yokoi D, Atsuta N, Watanabe H, Nakamura R, Hirakawa A, Ito M, Watanabe H, Katsuno M, Izumi Y, Morita M, Taniguchi A, Oda M, Abe K, Mizoguchi K, Kano O, Kuwabara S, Kaji R, Sobue G. Age of onset differentially influences the progression of regional dysfunction in sporadic amyotrophic lateral sclerosis. J Neurol 263:1129-1136, 2016
Kido H, Kano O (EQ) et al. Kikuchi-Fujimoto disease (histiocytic necrotizing lymphadenitis) with atypical encephalitis and painful testitis: a case report. BMC Neurol 17:22-26, 2017
Abe K, Aoki M, Tsuji S, Itoyama Y, Sobue G, Togo M, Hamada C, Tanaka M, Akimoto M, Nakamura K, Takahashi F, Kondo K, Yoshino H, Abe K, Aoki M, Tsuji S, Itoyama Y, Sobue G, Togo M, Hamada C, Sasaki H, Yabe I, Doi S, Warita H, Imai T, Ito H, Fukuchi M, Osumi E, Wada M, Nakano I, Morita M, Ogata K, Maruki Y, Ito K, Kano O, Yamazaki M, Takahashi Y, Ishiura H, Ogino M, Koike R, Ishida C, Uchiyama T, Mizoguchi K, Obi T, Watanabe H, Atsuta N, Aiba I, Taniguchi A, Sawada H, Hazama T, Fujimura H, Kusaka H, Kunieda T, Kikuchi H, Matsuo H, Ueyama H, Uekawa K, Tanaka M, Akimoto M, Ueda M, Murakami A, Sumii R, Kudou T, Nakamura K, Morimoto K, Yoneoka T, Hirai M, Sasaki K, Terai H, Natori T, Matsui H, Kotani K, Yoshida K, Iwasaki T, Takahashi F, Kondo K, Yoshino H：Safety and efficacy of edaravone in well defined patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled trial. Lancet Neurol 16:505-512, 2017
Abe K, Aoki M, Tsuji S, Itoyama Y, Sobue G, Togo M, Hamada C, Sasaki H, Yabe, I, Doi S, Warita H, Imai T, Ito H, Fukuchi M, Osumi E, Wada M, Nakano I, Morita M, Ogata K, Maruki Y, Ito K, Kano O, Yamazaki I, Takahashi Y, Ishiura H, Ogino M, Koike R, Ishida C, Uchiyama T, Mizoguchi K, Obi T, Watanabe H, Atsuta N, Aiba I, Taniguchi A, Sawada H, Hazama T, Fujimura H, Kusaka H, Kunieda T, Kikuchi H, Matsuo H, Ueyama H, Uekawa K, Tanaka M, Akimoto M, Nakamura K, Ueda M, Kotani K, Matsui H, Yoneoka T, Morimoto K, Sasaki K, Hirai N, Murakami A, Natori T, Sumii R, Terai H, Kudou T, Takahashi F, Iwasaki T, Kondo K, Yoshino H：EDARAVONE MCI-186 ALS 19 STUDY GRP：Open-label 24-week extension study of edaravone (MCI-186) in amyotrophic lateral sclerosis. Amyotroph Lateral Scler Frontotemporal Degener. 18:55-63, 2017
Tohnai G, Nakamura R, Sone J, Nakatochi M, Yokoi D, Katsuno M, Watanabe H, Watanabe H, Ito M, Li Y, Izumi Y, Morita M, Taniguchi A, Kano O, Oda M, Kuwabara S, Abe K, Aiba I, Okamoto K, Mizoguchi K, Hasegawa K, Aoki M, Hattori N, Onodera O, Naruse H, Mitsui J, Takahashi Y, Goto J, Ishiura H, Morishita S, Yoshimura J, Doi K, Tsuji S, Nakashima K, Kaji R, Atsuta N, Sobue G：Frequency and characteristics of the TBK1 gene variants in Japanese patients with sporadic amyotrophic lateral sclerosis. Neurobiol Aging 64:158.e15-158.e19, 2018
Kano O et al. Neuronal apoptosis inhibitory protein is implicated in amyotrophic lateral sclerosis symptoms. Sci Rep 8:6, 2018
Nagayama H, Kano O, Murakami H, Ono K, Hamada M, Toda T, Sengoku R, Shimo Y, Hattori N. Effect of istradefylline on mood disorders in Parkinson's disease. J Neurol Sci. 15;396:78-83, 2019
Hayashi N, Atsuta N, Yokoi D, Nakamura R, Nakatochi M, Katsuno M, Izumi Y, Kanai K Hattori N, Taniguchi A, Morita M, Kano O, Shibuya K, Kuwabara S, Suzuki N, Aoki M, Aiba I, Mizoguchi K, Oda M, Kaji R, Sobue G：Prognosis of amyotrophic lateral sclerosis patients undergoing tracheostomy invasive ventilation therapy in Japan. J Neurol Neurosurg Psychiatry. 91:285-290, 2020
Turner MR, Barohn RJ, Corcia P, Fink JK, Harms MB, Kiernan MC, Ravits J, Silani V, Simmons Z, Statland J, van den Berg LH; Delegates of the 2nd International PLS Conference, Mitsumoto H. Primary lateral sclerosis: consensus diagnostic criteria. J Neurol Neurosurg Psychiatry. 91(4):373-377, 2020
Nakamura R, Tohnai G, Atsuta N, Nakatochi M, Hayashi N, Watanabe H, Yokoi D, Watanabe H, Katsuno M, Izumi Y, Taniguchi A, Kanai K, Morita M, Kano O, Kuwabara S, Oda M, Abe K, Aoki M, Aiba I, Okamoto K, Mizoguchi K, Hattori N, Nakashima K, Kaji R, Sobue G; Japanese Consortium for Amyotrophic Lateral Sclerosis Research (JaCALS). Genetic and functional analysis of KIF5A variants in Japanese patients with sporadic amyotrophic lateral sclerosis. Neurobiol Aging. 17:S0197-4580(20)30226-8, 2020
Nakamura R, Misawa K, Tohnai G, Nakatochi M, Furuhashi S, Atsuta N, Hayashi N, Yokoi D, Watanabe H, Watanabe H, Katsuno M, Izumi Y, Kanai K, Hattori N, Morita M, Taniguchi A, Kano O, Oda M, Shibuya K, Kuwabara S, Suzuki N, Aoki M, Ohta Y, Yamashita T, Abe K, Hashimoto R, Aiba I, Okamoto K, Mizoguchi K, Hasegawa K, Okada Y, Ishihara T, Onodera O, Nakashima K, Kaji R, Kamatani Y, Ikegawa S, Momozawa Y, Kubo M, Ishida N, Minegishi N, Nagasaki M, Sobue G. A multi-ethnic meta-analysis identifies novel genes, including ACSL5, associated with amyotrophic lateral sclerosis. Commun Biol. 2020 Sep 23;3(1):526.
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