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Assistant Professor
Toho University Faculty of Medicine, Japan
I do not have any relevant financial / non-financial relationships with any proprietary interests.
Takehisa Hirayama, M.D., Ph.D.
Assistant Professor
Department of Neurology
Toho University Faculty of Medicine
6-11-1 Omorinishi Ota-ku
Tokyo 143-8541 Japan
Phone: +81-3-3762-4151
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Education
1999-2004 M.D. in Faculty of Medicine
Toho University, Tokyo, Japan
2007-2011 Ph.D. in Department of Neurology
Graduate School of Medicine, Toho University, Tokyo, Japan
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Medical Training and Professional Experiences
2005-2006 Resident in Department of Neurology
Toho University Ohashi Medical Center, Tokyo, Japan
2008-2009 Resident in Mishuku Hospital, Tokyo, Japan
2010 Neuroradiology Resident in Department of Radiology
Juntendo University, Tokyo, Japan
Neuropathology Resident in Tokyo Metropolitan Institute for Neuroscience, Tokyo, Japan
2017-2019 Medical director in Mishuku Hospital, Tokyo, Japan
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Academic Appointments
2014-2016, 2020-present Assistant Professor
Department of Neurology
Toho University Faculty of Medicine, Tokyo, Japan
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Specialty Boards
Board Certified Member of the Japanese Society of Internal Medicine (2008)
Japanese Board of Neurology (2011)
Japanese Board of Stroke (2012)
Japanese Board of Dementia (2015)
Fellow of the Japanese Society of Internal Medicine (2016)
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Honors and Awards
Japan Amyotrophic Lateral Sclerosis Association (2021)
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Publications
Hirayama T, et al. Clinicoradiological features of recurrent ischemic stroke. Healthcare for poststroke patients. J Multidiscip Healthc 3: 97-101, 2010
Hirayama T, et al. Unilateral measles-associated retrobulbar optic neuritis without encephalitis: A case report and literature review. Case Rep Neurol 2: 128-132, 2010
Takazawa T, Ikeda K, Hirayama T, Kawabe K, Nakamura Y, Kano O, Yoshii Y, Tanaka F, Sobue G, Iwasaki Y. Familial amyotrophic lateral sclerosis with a novel G85S mutation of superoxide dismutase 1 gene: clinical features of lower motor neuron disease. Intern Med 49: 183-186, 2010
Ikeda K, Nakamura Y, Hirayama T, Sekine T, Nagata R, Kano O, Kawabe K, Kiyozuka T, Tamura M, Iwasaki Y. Cardiovascular risk and neuroradiological profiles in asymptomatic vertebrobasilar dolichoectasia. Cerebrovasc Dis 30: 23-28, 2010
Ishikawa Y, Hirayama T, Nakamura Y, Ikeda K. Incidental cerebral aneurysms in acute stroke patients: Comparison of asymptomatic healthy controls. J Neurol Sci 298: 42-45, 2010
Hirayama T, et al. Zonisamide treatment delays motor neuron degeneration and astrocyte proliferation in wobbler mice. J Neurology Res 1: 139-144, 2011
Ikeda K, Hirayama T, Iwamoto K, Takazawa T, Kawase Y, Yoshii Y, Kano O, Kawabe K, Tamura M, Iwasaki Y: Pulse wave velocity study in middle-aged migraineurs at low risk cardiovascular disease risk. Headache 51: 1239-1244, 2011
Ikeda K, Kawagoe N, Hirayama T, Nagaoka T, Iwamoto K, Kano O, Kawabe K, Iwasaki Y: Brain MRI depiction of multiple cranial neuropathies in neurosarcoidosis: A case report. J Neurology Res 1: 121-123, 2011
Aoyagi J, Ikeda K, Kiyozuka T, Hirayama T, Ishikawa Y, Sato R, Yoshii Y, Kawabe K, Iwasaki Y: Alleviation of brain hypoperfusion after preventative treatment with lomerizine in an elderly migraineur with aura. Int J Mol Imaging 10: 1155-9, 2011
Ikeda K, Nakamura Y, Kiyozuka T, Aoyagi J, Hirayama T, Nagata R, Ito H, Iwamoto K, Murata K, Yoshii Y, Kawabe K, Iwasaki Y: Serological profiles of urate, paraoxonase 1, ferritin and lipid in Parkinson’s disease: Changes linked to disease progression. Neurodegenerative Dis 8: 252-258, 2011
Ikeda K, Ito H, Hidaka T, Takazawa T, Sekine T, Yoshii Y, Hirayama T, Kawabe K, Kano O, Iwasaki Y: Repeated non-enhancing tumefactive lesions in a patient with a neuromyelitis optica spectrum disorder. Intern Med 50: 1061-1064, 2011
Nakamura Y, Hirayama T, Ikeda K: Clinicoradiological features of vertebrobasilar dolichoectasia in stroke patients. J Stroke Cerebrovasc Diseases 21: 5-10, 2012
Nagaoka T, Ikeda K, Hirayama T, Yamamoto T, Iwasaki Y: Wegener granulomatosis-associated optic perineural hypertrophy and optic neuropathy. Intern Med 51: 227-228, 2012
Murata K, Ikeda K, Muto M, Hirayama T, Kano O, Iwasaki Y: A case of posterior spinal artery syndrome in the cervical cord: a review of the clinicoradiological literature. Intern Med 51: 803-807, 2012
Miura K, Nagaoka T, Ikeda K, Hirayama T, Kawabe K, Iwasaki Y: A case of inferolateral oculomotor fascicular infarction: a review of the clinicoradiological literature. Intern Med 51: 921-924, 2012
Ikeda K, Hirayama T, Kawabe K, Kano O, Iwasaki Y: Serum lipid, creatinine, urate and ferritin levels at the first time diagnosed with amyotrophic lateral sclerosis (ALS) contribute to disease progression. Intern Med 51: 1501-1508, 2012
Ikeda K, Hirayama T, Takazawa T, Kawabe K, Iwasaki Y: Relationships between disease progression and serum levels of lipid, urate, creatinine and ferritin in Japanese patients with amyotrophic lateral sclerosis: a cross-sectional study. Intern Med 51: 1501-1508, 2012
Ikeda K, Hirayama T, Takazawa T, Iwasaki Y: Levetiracetam protects spinal motor neurons against glutamate-induced neurotoxicity in culture. J Neurology Res 2: 39-43, 2012
Sekine T, Ikeda K, Hirayama T, Suzuki A, Iwasaki Y: Transient splenial lesion after recovery of cerebral vasoconstriction and posterior reversible encephalopathy syndrome: a case report of eclampsia. Intern Med 51: 1407-1411, 2012
Kishimoto Y, Ikeda K, Murata K, Kawabe K, Hirayama T, Iwasaki Y: Rapid development of central pontine myelinolysis after recovery from Wernicke encephalopathy: a non-alcoholic case without hyponatremia. Intern Med 51: 1599-1603, 2012
Takazawa T, Ikeda K, Murata K, Kawase Y, Hirayama T, Ohtsu M, Harada H, Totani T, Sugiyama K, Kawabe K, Kano O, Iwasaki Y: Sudden deafness and facial diplegia in Guillain-Barré Syndrome: radiological depiction of facial and acoustic nerve lesions. Intern Med 51: 2433-2437, 2012
Kiyozuka T, Hirayama T, Ikeda K, Kawabe K, Iwasaki Y: Alternating progression of pontine infarction: a case report. J Neurology Res 3: 42-45, 2013
Takazawa T, Ikeda K, Nagaoka T, Hirayama T, Yamamoto T, Yanagihashi M, Tochikubo T, Iwasaki Y: Wegener granulomatosis-associated optic perineuritis. Orbit, Early Online 10: 1-4, 2013
Ishikawa Y, Ikeda K, Murata K, Hirayama T, Takazawa T, Yanagihashi M, Kawabe K, Takahashi Y, Iwasaki Y: Ophthalmoplegia and flaccid paraplegia in anti-NMDA receptor encephalitis: A case report and literature review. Internal Med 52: 2811-5, 2013
Ikeda K, Iwamoto K, Takazawa T, Kawase K, Hirayama T, Ishikawa Y, Kawabe K, Iwasaki Y: Scopolamine-induced migrainous headache. Cephalalgia 33: 957, 2013
Kano O, Urita Y, Ito H, Takazawa T, Kawase Y, Murata K, Hirayama T, Miura K, Ishikawa Y, Kiyozuka T, Aoyagi J, Iwasaki Y: Dopamine effective in preventing rivastigmine-related gastrointestinal disturbances in patients with Alzheimer’s disease. Neuropsychiatric Disease Treatment 9: 1411-5, 2013
Ikeda K, Murata K, Kawase Y, Kawabe K, Kano O, Yoshii Y, Takazawa T, Hirayama T, Iwasaki Y: Relationship between cervical cord 1H-magnetic resonance spectroscopy and clinico-electromyographic profile in amyotrophic lateral sclerosis. Muscle Nerve 47: 61-67, 2013
Kano O, Ito H, Takazawa T, Kawase Y, Murata K, Iwamoto K, Nagaoka T, Hirayama T, Miura K, Nagata R, Kiyozuka T, Aoyagi J, Sato R, Eguchi T, Ikeda K, Iwasaki Y: Clinically meaningful treatment responses after switching galantamine and with addition of memantine in patients with Alzheimer’s disease receiving donepezil. Neuropsychiatric Disease Treatment 9: 259-265, 2013
Hirayama T, et al. A case of superficial hemisensory dysfunction due to operculo-insular infarction: Radiological depiction of thalamocortical projections to the secondary somatosensory cortex. J Stroke Cerebrovasc Dis 23: 187-90, 2014
Maeda T, Yoshizawa S, Hirayama T, Saga T, Terada K, Urita Y: Neurosyphilis mimicking Ramsay Hunt syndrome. J Nippon Med Sch 82: 254-256, 2015
Ikeda K, Hirayama T, Takazawa T, Kawabe K, Iwasaki Y: Transdermal patch of rotigotine attenuates freezing of gait in patients with Parkinson's disease: An open-label comparative study of three non-ergot dopamine receptor agonists. Intern Med 55: 2765-2769, 2016
Ikeda K, Sawada M, Morioka H, Kyuzen M, Ebina J, Nagasawa J, Yanagihashi M, Miura K, Ishikawa Y, Hirayama T, Takazawa T, Kano O, Kawabe K, Iwasaki Y: Clinical profile and changes of serum lipid levels in epileptic patients after cerebral infarction. J Stroke Cerebrovasc Dis 26: 644-649, 2017
Ikeda K, Hanashiro S, Ishikawa Y, Sawada M, Kyuzen M, Morioka H, Ebina J, Nagasawa J, Yanagihashi M, Miura K, Hirayama T, Takazawa T, Kano O, Kawabe K, Iwasaki Y: Treatment with telmisartan, a long-acting angiotensin II receptor blocker, prevents migraine attacks in Japanese non-responders to lomerizine. Neurol Sci 38: 827-831, 2017
Ikeda K, Yanagihashi M, Miura K, Ishikawa Y, Hirayama T, Takazawa T, Kano O, Kawabe K, Mizumura N, Iwasaki Y: Zonisamide cotreatment delays striatal dopamine transporter reduction in Parkinson disease: A retrospective, observational cohort study. J Neurol Sci 15: 391:5-9, 2018
Hirayama T, et al. An autopsy case of Lambl’s excrescences with Trousseau syndrome that caused cardioembolic stroke. Intern Med 59: 3085-3088, 2020
Hirayama T, et al. Guillain-Barré syndrome after COVID-19 in Japan. BMJ Case Rep 13: e239218, 2020
Hirayama T, et al. Communicating the diagnosis: a survey of patients with amyotrophic lateral sclerosis and their families in Japan. Acta Neurol Belg: 122 :471-478, 2021
Yanagihashi M, Sugisawa T, Fuchimoto M, Saotome Y, Onozawa K, Matsumoto Y, Bokuda K, Ebina J, Shibukawa M, Hirayama T, Murakami Y, Washizawa N, Ebihara S, Kano O: Contradictory Responses to the COVID-19 Pandemic in Amyotrophic Lateral Sclerosis Patients and Their Families and Caregivers in Japan. Intern Med 60: 1519-1524, 2021
Morioka H, Hirayama T (EQ), et al. Robot-assisted training using hybrid assistive limb ameliorates gait ability in patients with amyotrophic lateral sclerosis. J Clin Neurosci 99: 158-163, 2022
Morioka H, Murata K, Sugisawa T, Shibukawa M, Ebina J, Sawada M, Hanashiro S, Nagasawa J, Yanagihashi M, Hirayama T, Uchi M, Kawabe K, Ebihara S, Murakami Y, Nakajima T, Kano O. Effects of Long-term Hybrid Assistive Limb Use on Gait in Patients with Amyotrophic Lateral Sclerosis. Intern Med. 2022;61(10):1479-1484.
