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Assistant professor
The Ohio State University
I do not have any relevant financial / non-financial relationships with any proprietary interests.
OMB No. 0925-0001 and 0925-0002 (Rev. 10/2021 Approved Through 09/30/2024) ________________________________________
BIOGRAPHICAL SKETCH
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NAME: Li, Jinghua
eRA COMMONS USER NAME (credential, e.g., agency login): jinghua_li
POSITION TITLE: Assistant Professor
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable. Add/delete rows as necessary.)
INSTITUTION AND LOCATION DEGREE
(if applicable) END DATE
MM/YYYY FIELD OF STUDY
Shandong University, Jinan, Shandong BS 06/2011 Biological Sciences
Duke University, Durham, North Carolina PHD 05/2016 Chemistry
Northwestern University, Evanston, Illinois Postdoctoral Fellow 08/2019 Materials Science and Engineering
A. Personal Statement
I am an assistant professor of materials science and engineering, beginning in September 2019. Prior to joining Ohio State, I worked as a postdoctoral fellow with Professor John A. Rogers in the Department of Materials Science and Engineering at Northwestern University. I graduated from Duke University in May 2016 with a Ph.D. in Chemistry. I aim to make a significant impact on the fields of biochemical sensors, bio-integrated electronics, and brain-machine interfaces through interdisciplinary studies. These goals align well with the my duties as a tenure-track assistant professor in Department of Materials Science and Engineering and the Chronic Brain Injury Program at The Ohio State University, which aim to improve understanding, detection, and treatment of infectious and neurological diseases through interdisciplinary knowledge and expertise in materials science, electrical engineering and neuroscience.
I have published research articles and review papers in peer-reviewed journals such as Nature Materials, Proceedings of the National Academy of Sciences of the United States of America, Advanced Materials, Nano Letters, ACS Nano and Biosensors and Bioelectronics. These articles focus on topics including neural interfaces, bio-integrated electronics, thin-film electronics and biosensing.
1. Chen S, Dong Y, Liu T, Li J. Waterproof, flexible field-effect transistors with submicron monocrystalline Si nanomembrane derived encapsulation for continuous pH sensing. Biosensors and Bioelectronics. 2022 January; 195:113683-. Available from: https://linkinghub.elsevier.com/retrieve/pii/S095656632100720X DOI: 10.1016/j.bios.2021.113683
2. Song E, Li J, Won SM, Bai W, Rogers JA. Materials for flexible bioelectronic systems as chronic neural interfaces. Nat Mater. 2020 Jun;19(6):590-603. PubMed PMID: 32461684.
3. Li J, Song E, Chiang CH, Yu KJ, Koo J, Du H, Zhong Y, Hill M, Wang C, Zhang J, Chen Y, Tian L, Zhong Y, Fang G, Viventi J, Rogers JA. Conductively coupled flexible silicon electronic systems for chronic neural electrophysiology. Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):E9542-E9549. PubMed Central PMCID: PMC6187144.
4. Li J, Franklin AD, Liu J. Gate-Free Electrical Breakdown of Metallic Pathways in Single-Walled Carbon Nanotube Crossbar Networks. Nano Lett. 2015 Sep 9;15(9):6058-65. PubMed PMID: 26263184.
B. Positions, Scientific Appointments and Honors
Positions and Scientific Appointments
2019 - Assistant Professor, The Ohio State University, Columbus, OH
Honors
2015 - 2016 Paul M. Gross Fellowship, Paul M. Gross Fellowship Foundation
2015 Outstanding Poster Award, 129th NC ACS Local Section Meeting
2015 Duke University Graduate School Conference Travel Fellowship, Duke University
2015 Electrochemical Society Travel Grant, Electrochemical Society
C. Contribution to Science
1. My research focuses on the implementation of thin-film materials for biochemical and biophysical sensing to extend the frontier of human healthcare. Our team works on the design and innovation of Si nanomembranes as interfaces to the brain with multidecade lifetimes under physiological conditions. The technology enables flexible biochemical sensors and micro-electrocorticographic (μECoG) electrodes with on-chip signal processing and multiplexing capabilities for recording and stimulation in nervous systems with chronic stability, high sensitivity, and unprecedented level of spatiotemporal resolution.
a. Chen S, Dong Y, Liu T, Li J. Waterproof, flexible field-effect transistors with submicron monocrystalline Si nanomembrane derived encapsulation for continuous pH sensing. Biosensors and Bioelectronics. 2022 January; 195:113683-. Available from: https://linkinghub.elsevier.com/retrieve/pii/S095656632100720X DOI: 10.1016/j.bios.2021.113683
b. Song E, Li J, Won SM, Bai W, Rogers JA. Materials for flexible bioelectronic systems as chronic neural interfaces. Nat Mater. 2020 Jun;19(6):590-603. PubMed PMID: 32461684.
c. Chiang CH, Won SM, Orsborn AL, Yu KJ, Trumpis M, Bent B, Wang C, Xue Y, Min S, Woods V, Yu C, Kim BH, Kim SB, Huq R, Li J, Seo KJ, Vitale F, Richardson A, Fang H, Huang Y, Shepard K, Pesaran B, Rogers JA, Viventi J. Development of a neural interface for high-definition, long-term recording in rodents and nonhuman primates. Sci Transl Med. 2020 Apr 8;12(538) PubMed Central PMCID: PMC7478122.
d. Li J, Song E, Chiang CH, Yu KJ, Koo J, Du H, Zhong Y, Hill M, Wang C, Zhang J, Chen Y, Tian L, Zhong Y, Fang G, Viventi J, Rogers JA. Conductively coupled flexible silicon electronic systems for chronic neural electrophysiology. Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):E9542-E9549. PubMed Central PMCID: PMC6187144.
2. In addition to neural interfaces, my research also focuses on the design and manufacturing of various types of bio-integrated electronics capable of continuously measuring high-quality biophysical and biochemical signals. Examples include skin-interfaced electronic tattoos for recording electromyography (EMG) and electroencephalography (EEG) signals, and multifunctional pressure and temperature sensors derived from SiC nanomembranes. The sensing platform can also find broad applications in areas related to advanced healthcare.
a. Chandra S, Li J, Afsharipour B, Cardona AF, Suresh NL, Tian L, Deng Y, Zhong Y, Xie Z, Shen H, Huang Y, Rogers JA, Rymer WZ. Performance Evaluation of a Wearable Tattoo Electrode Suitable for High-Resolution Surface Electromyogram Recording. IEEE Trans Biomed Eng. 2021 Apr;68(4):1389-1398. PubMed Central PMCID: PMC8015348.
b. Phan HP, Zhong Y, Nguyen TK, Park Y, Dinh T, Song E, Vadivelu RK, Masud MK, Li J, Shiddiky MJA, Dao D, Yamauchi Y, Rogers JA, Nguyen NT. Long-Lived, Transferred Crystalline Silicon Carbide Nanomembranes for Implantable Flexible Electronics. ACS Nano. 2019 Oct 22;13(10):11572-11581. PubMed PMID: 31433939.
c. Tian L, Zimmerman B, Akhtar A, Yu KJ, Moore M, Wu J, Larsen RJ, Lee JW, Li J, Liu Y, Metzger B, Qu S, Guo X, Mathewson KE, Fan JA, Cornman J, Fatina M, Xie Z, Ma Y, Zhang J, Zhang Y, Dolcos F, Fabiani M, Gratton G, Bretl T, Hargrove LJ, Braun PV, Huang Y, Rogers JA. Large-area MRI-compatible epidermal electronic interfaces for prosthetic control and cognitive monitoring. Nat Biomed Eng. 2019 Mar;3(3):194-205. PubMed PMID: 30948811.
d. Li J, Zhao J, Rogers JA. Materials and Designs for Power Supply Systems in Skin-Interfaced Electronics. Acc Chem Res. 2019 Jan 15;52(1):53-62. PubMed PMID: 30525449.
3. Materials at nanometer scale can demonstrate unique and outstanding electrical/mechanical properties different from those in bulk forms. Therefore, the controlled synthesis of nanomaterials is of interests for the development of advanced nanoelectronics and bioelectronics. We aim to understand the chemical equilibrium of pyrolysis and nucleation of carbon-containing molecules at metal/carbon interfaces for the controlled synthesis of graphitic carbon nanostructures (e.g. carbon nanotubes) using chemical vapor deposition method. We are interested in how electronic structures and bandgaps of nanocarbons can affect their reactivity with oxygen-containing molecules to achieve selective synthesis and purification. Based on these understandings, We develop synthetic strategies to design sp2 C-C formation reactions to form carbon nanotubes with tailored alignment, chirality, and electrical properties. These studies provide important insights into the control of the electronic structures of graphitic carbon-based materials and the development of biochemical interfaces for the detection of biomarkers with high sensitivity and selectivity.
a. Li J, Otsuka K, Zhang X, Maruyama S, Liu J. Selective synthesis of large diameter, highly conductive and high density single-walled carbon nanotubes by a thiophene-assisted chemical vapor deposition method on transparent substrates. Nanoscale. 2016 Aug 7;8(29):14156-62. PubMed PMID: 27382988.
b. Li J, Franklin AD, Liu J. Gate-Free Electrical Breakdown of Metallic Pathways in Single-Walled Carbon Nanotube Crossbar Networks. Nano Lett. 2015 Sep 9;15(9):6058-65. PubMed PMID: 26263184.
c. Li J, Ke CT, Liu K, Li P, Liang S, Finkelstein G, Wang F, Liu J. Importance of diameter control on selective synthesis of semiconducting single-walled carbon nanotubes. ACS Nano. 2014 Aug 26;8(8):8564-72. PubMed PMID: 25111952.
d. Li J, Liu K, Liang S, Zhou W, Pierce M, Wang F, Peng L, Liu J. Growth of high-density-aligned and semiconducting-enriched single-walled carbon nanotubes: decoupling the conflict between density and selectivity. ACS Nano. 2014 Jan 28;8(1):554-62. PubMed PMID: 24295396.
