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Professor of Neurology
Harvard Medical School
Boehringer Ingelheim (Products/Services: Yes) (Consultant)Takeda (Products/Services: Yes) (Advisory Board)
Board certified in both vascular and critical care neurology; I am a clinician-scientist with expertise in genetics. The hallmark of my scientific work is the combination of careful clinical characterization of patients with the most rigorous approaches to genetics. As scientist, clinician, educator and leader, I have created a legacy of multidisciplinary teams that are successfully tackling pressing challenges in brain disease. I have overseen a longitudinal cohort study of intracerebral hemorrhage (ICH) since 2001 and have directed multi-center observational studies of ICH. My lab is a leading contributor to the performance and analysis of high-throughput genome-wide association and sequencing studies in stroke and related traits. My published studies of ICH, carried out with a distinguished group of collaborators, have made major contributions to understanding its risk factors, its acute clinical course, and high risk of VCID and recurrent stroke for survivors of ICH. I founded the International Stroke Genetics Consortium to bring together the world’s pre-eminent stroke investigators and launched the NIH-funded Cerebrovascular Disease Knowledge Portal to share data widely. I have trained a generation of national leaders in neurocritical care, stroke and clinical investigation. I served as Program Director for Harvard’s clinical training programs in both stroke and neurocritical care and am Principal investigator of the NIH-funded investigator training program Recovery and Restoration of Central Nervous System Health and Function After Injury. My lab has been the training ground for outstanding investigators who have gone on to establish their own independent research programs at top academic institutions in the US and abroad. I serve as center director for our newly launched American Stroke Association-Bugher Foundation Center for Excellence in Brain Health for Hemorrhagic Stroke. In April 2020, the McCance Center, which I direct, launched a specialized clinic devoted to restoring brain health following COVID-19 infection, and convened the Boston-wide COVID-19-Brain Health and Functional Outcomes Collaborative, which continues to meet weekly to nurture, coordinate and stimulate research and clinical innovation devoted to reducing the impact of COVID-19 on the nervous system and improving the lives of individuals with PASC-related nervous system dysfunction.
