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Professor
Northwestern University
SPR therapeutic (Products/Services: Yes) (Research Grant)
OMB No. 0925-0001 and 0925-0002 (Rev. 09/17 Approved Through 03/31/2020)
BIOGRAPHICAL SKETCH
NAME: Nader, Antoun
eRA COMMONS USER NAME: anader
POSITION TITLE: Professor of Anesthesiology & Orthopedic Surgery
EDUCATION/TRAINING
INSTITUTION AND LOCATION DEGREE
(if applicable)
Completion Date
MM/YYYY
FIELD OF STUDY
Lebanese University M.D. 12/1990 Medicine
American University of Beirut Residency 06/1993 Anesthesiology
University of Iowa
Rush University Fellowship
Internship 06/1994
06/1995 Neuro-Anesthesiology
Surgery
Stroger Hospital Residency 06/1998 Anesthesiology
Stroger Hospital Fellowship 06/1999 Pain Management
A. Personal Statement
My medical education, fellowship training and research interests make me well-suited to serve as co-investigator on this topic. During my last year of residency training, I was awarded by the American Society of Regional Anesthesia and Pain Medicine a funded fellowship to study the effect of dopamine on a rat model a Complex Regional Pain Syndrome created by loose ligation of the sciatic nerve. After my residency, I pursued a fellowship in acute and chronic pain management mostly treating patients with acute, subacute pain, and chronic neuropathic pain.
I am currently the section chief for acute pain management in the Anesthesiology department at the Feinberg School of medicine and the medical director for pain management at Northwestern Memorial Hospital. Over the last 20 years, I practice interventional pain management with a focus on spinal pain and minimally invasive spinal interventions, as well as perioperative and inpatient pain management. My clinical research focuses on the study of pain mechanism and the development of new diagnostic and therapeutic modalities for clinical pain conditions, including perioperative acute pain management. I am currently engaged in multiple clinical research studies in chronic pain and surgical pain treatment, including novel analgesia clinical trials and imaging as well as in clinical trials on optimal perioperative pain management in patients with substance use disorders. I am enthusiastic in applying my expertise in pain management, and clinical research in assisting in this study.
Selected peer-reviewed publications.
1. Gilmore AC, MD, Ilfeld BM, Rosenow JM, Li S, Desai M, Hunter CW, Rauck RL, Kapural LL, Nader A, Mak J, Cohen SP, Crosby ND, Boggs JW: Percutaneous Peripheral Nerve Stimulation for the Treatment of Chronic Neuropathic Post-Amputation Pain: A Multicenter Randomized Placebo-Controlled Trial: Reg Anesth Pain Med. 2019 Jun;44(6):637-645
2. Gilmore CA, Ilfeld BM, Rosenow JM, Li S, Desai MJ, Hunter CW, Rauck RL, Nader A, Mak J, Cohen SP, Crosby ND, Boggs JW. Percutaneous 60-day Peripheral Nerve Stimulation Implant Provides Sustained Relief of Chronic Pain Following Amputation: 12-month Follow-Up of a Randomized, Double-Blind, Placebo-Controlled Trial. Reg Anesth Pain Med. 2019; 44:637–645
3. Neuman MD, Feng R, Carson JL, Gaskins LJ, Dillane D, Sessler DI, Sieber F, Magaziner J, Marcantonio ER, Mehta S, Menio D, Ayad S, Stone T, Papp S, Schwenk ES, Elkassabany N, Marshall M, Jaffe JD, Luke C, Sharma B, Azim S, Hymes RA, Chin KJ, Sheppard R, Perlman B, Sappenfield J, Hauck E, Hoeft MA, Giska M, Ranganath Y, Tedore T, Choi S, Li J, Kwofie MK, Nader A, Sanders RD, Allen BFS, Vlassakov K, Kates S, Fleisher LA, Dattilo J, Tierney A, Stephens-Shields AJ, Ellenberg SS; REGAIN Investigators. Spinal Anesthesia or General Anesthesia for Hip Surgery in Older Adults. N Engl J Med. 2021 Oct 9. doi: 10.1056/NEJMoa2113514. Online ahead of print. PMID: 34623788
4. Book editor: Chronic Pain Management in General and Hospital Practice: K Shimoji, A Nader, W Hamann - 2020 - Springer ISBN 978-981-15-2932-0 ISBN 978-981-15-2933-7 (eBook) https://doi.org/10.1007/978-981 -15-2933-7 © Springer Nature Singapore Pte Ltd. 2021
B. Positions and Honors
Positions and Employment
1999-2001 Assistant Professor, Department of Anesthesiology
Rush Medical College, Chicago, IL.
2001-2005 Assistant Professor, Department of Anesthesiology
Northwestern University, the Feinberg School of Medicine
2005-Present Section Chief, Regional Anesthesiology and Acute Pain
Department of Anesthesiology Northwestern Memorial Hospital, Chicago, IL
2006-2012 Associate Professor, Department of Anesthesiology
Northwestern University, the Feinberg School of Medicine
2009- Present Medical Director, Acute Pain Medicine
2011- Present Fellowship Co-Director: Adult and Pediatric Regional Anesthesia and Acute Pain fellowship, Northwestern University, Feinberg School of Medicine
2010-2012 Associate Professor, Department of Orthopedics
Northwestern University, the Feinberg School of Medicine
2012-Present Professor, Department of Anesthesiology
Northwestern University, the Feinberg School of Medicine
Honors and Awards:
1996-1997 Best project of the year - Cook County Hospital, Department of
Anesthesiology & Pain Management 1835 W. Harrison Street, Chicago, IL
1997-1998 Robert D. Dripps, MD - Memorial Award Presented to the Outstanding
Graduate Resident in Anesthesiology
1998 Outstanding Scientific Presentation - Sigma XI Society-Rush University Chapter
1998-1999 Braun Research/Pain Fellowship Award - awarded by the American Society of Regional Anesthesia for “The role of Dopamine in Neuropathic Pain” (National Competition)
2008-2009 Golden Apple Award for Excellence in Resident Education - Department
Of Anesthesiology, Northwestern University Feinberg School of Medicine
2012 Feinberg School of Medicine Eighth Annual Lewis Landsberg Research Day. Third Place for Clinical Science Research
2016 Feinberg School of Medicine Eighth Annual Lewis Landsberg Research Day. First Place for Clinical Science Research
2016 Best of Meeting Award for ASRA’s 41st Annual Regional Anesthesiology and Acute Pain Medicine
2019 Clinical Science Research Award: post-amputation pain study abstract, American Society of Pain & Neuroscience 2019 Conference, Miami, FL, July 2019
2019 Best in Meeting Award: American Society of Regional Anesthesia and Pain Medicine, November 2019
C. Contribution to Science
1. As a pain management fellow, I was interested in reversing the effect of a Complex Regional Pain Syndrome in an animal model and patients. In a rat model, I induced a neuropathic pain syndrome by performing a loose ligation around the sciatic nerve, and I was able to reverse the effect by injecting intraperitoneal then intrathecal dopamine. After my fellowship, I continued to pursue acute and chronic pain management research. My interest focused on preventing a transition from acute to chronic pain after surgical or mechanical insult. I have studied the effect of minimizing acute pain in the immediate postop period by providing continuous analgesia in the epidural space and along the peripheral nerves.
a. Nader A, Kendall MC, Wixson RL, Chung B, Polakow LM, P.T., McCarthy RJ. A randomized trial of epidural analgesia followed by continuous femoral analgesia compared with oral opioid analgesia on short- and long-term functional recovery after total knee replacement. Pain Med. 2012 Jul;13(7):937-47
b. Hsu LP, OH S, Nuber GW, Doty R, Kendal MC, Gryzlo S, Nader A. Infrapatellar Branch of the Saphenous Nerve Block for Knee Arthroscopy: A prospective, double-blinded randomized, placebo-controlled trial. J Bone Joint Surg Am. 2013 Aug 21;95(16):1465-72
2. I also studied the effect of local anesthetics and steroid on another unique model of transition from acute to chronic neuropathic pain in trigeminal neuralgia and atypical facial pain:
a. Nader A, Kendall MC, Vanderby B, Chen J, Vanderby B, Rosenow JM, Bendok BR. Ultrasound-guided trigeminal nerve block via the pterygopalatine fossa: An effective treatment for trigeminal neuralgia and atypical facial pain. Pain Physician. 2013 Sep-Oct; 16(5): E537-45
b. Nader A, Bendok BR, JJ Prine, Kendall MC: Ultrasound-Guided Pulsed Radiofrequency Application via the Pterygopalatine Fossa: A Practical Approach to Treat Refractory Trigeminal Neuralgia. Pain physician 2015 May-Jun; 18(3): E411-5.
c. Nader A, Kendall MC. Landmarks of Ultrasound-Guided Trigeminal Block: Lateral Pterygoid Muscle. Pain Physician. 2015 Sep-Oct; 18(5)
3. Currently, in my pain practice, I treat patients with acute, subacute and chronic lower back and neck pain. I am well recognized in my society as a leader in this field as evident by numerous invitations to speak and teach different modalities of neuraxial and truncal pain management.
• Speaker: Regional Anesthesia: Perioperative outcomes: Topics in Anesthesia Chicago IL May 15
• Speaker: Ultrasound Guided Regional Anesthesia: What have we learned: Topics in Anesthesia Chicago IL May 15
• Workshop: Hip injection Demonstration. American Society of Regional Anesthesia and Pain Medicine Excellence in Pain Management Workshops Ultrasound Techniques: Northwestern University Chicago, IL June 2015
• Speaker: Basic Of Ultrasound: American Society of Regional Anesthesia and Pain Medicine Excellence in Pain Management Workshops Ultrasound Techniques: Northwestern University Chicago, IL June 2015
• Speaker: Clinical Applications and Evidence-Based Medicine in Ultrasound Regional Anesthesia for truncal and paravertebral blocks: ASRA-ASA Ultrasound-Guided Regional Anesthesia Education, Chicago, IL, November 2015
• Workshop: Head and Neck Blocks: Ultrasound Workshop. American Society of Anesthesiology Annual Meeting, San Diego. October 2015
• Workshop: Faculty ASRA-ASA Ultrasound-Guided Regional Anesthesia Education, Chicago, IL, November 2015
• Speaker: Ultrasound Guided Centroaxial and Truncal Blocks. Advanced Techniques for Acute and Chronic Pain Management: WSU School of Medicine Detroit, Michigan. May 2016
• Workshop: Sonography for Paravertebral and Intercostal Nerve Blocks, Spinal Advanced Techniques for Acute and Chronic Pain Management: WSU School of Medicine Detroit, Michigan. May 2016
• Workshop: Sonography for Paravertebral and Intercostal Nerve Blocks, Spinal Advanced Techniques for Acute and Chronic Pain Management: WSU School of Medicine, Detroit, Michigan. March. 2017
• Workshop: ASRA Pain Medicine and MSK Ultrasound Cadaver Course: Chicago, Il June 2017
• Workshop: Ultrasound-guided paravertebral, intercostal, and lumbar spine blocks: Society for Pain Practice Management Interventional Pain Management Course. Chicago Il, Sep 22-23, 2017
• Workshop: Ultrasound-guided brachial plexus and stellate ganglion blocks: Society for Pain Practice Management Interventional Pain Management Course. Chicago Il, Sep 22-23, 2017
• Speaker: Managing Orofacial Pain. Midwest Pain Society 41st Annual Scientific Meeting October 27 -28, 2017 Chicago, Illinois
• Workshop: Head and Neck Blocks: Ultrasound Workshop. American Society of Anesthesiology Annual Meeting, Boston. October 2017
• Course Director: ASRA-ASA Ultrasound-Guided Regional Anesthesia Education Portfolio Cadaver Course, Chicago, IL Nov 2017
• Workshop: Ultrasound for Spine Procedures. 2018 World Congress on Regional Anesthesia and Pain Medicine. New York, April 2018
• Workshop: Interventional Cancer Pain. 2018 World Congress on Regional Anesthesia and Pain Medicine New York, April 2018
• Workshop: MSK Ultrasound. 2018 World Congress on Regional Anesthesia and Pain Medicine. New York, April 2018
• Workshop: Ultrasound-Guided Interventions in Regenerative Medicine. 2018 World Congress on Regional Anesthesia and Pain Medicine. New York, April 2018
• Workshop: Chronic Pain Resident/Fellow workshop. 2018 World Congress on Regional Anesthesia and Pain Medicine. New York, April 2018
• Workshop: TMJ and muscles; ultrasound (model scans) American Interventional Headache Society meeting Chicago, IL, June 2018
• Workshop: ASRA Pain Medicine and MSK Ultrasound Cadaver Course: Chicago, Il June 2018
• Workshop: Ultrasound-guided paravertebral, intercostal, and lumbar spine blocks: Society for Pain Practice Management Interventional Pain Management Course. Chicago Il, Sep 2018
• Workshop: Ultrasound-guided brachial plexus and stellate ganglion blocks: Society for Pain Practice Management Interventional Pain Management Course. Chicago Il, Sep 2018
• Workshop: ASRA-ASA Ultrasound-Guided Regional Anesthesia Education Portfolio Cadaver Course, Chicago, IL Nov 2018
• Workshop: Hands-On Ultrasound Workshop Ultrasound in Pain Medicine I ASRA's 17th Annual Pain Medicine Meeting San Antonio, Texas November 15-17, 2018
• Workshop: Hands-On Ultrasound Workshop Ultrasound in Pain Medicine 2 ASRA's 17th Annual Pain Medicine Meeting San Antonio, Texas November 15-17, 2018
• Workshop: Cryoablation of Peripheral Nerves U/S ASRA's 17th Annual Pain Medicine Meeting San Antonio, Texas November 15-17, 2018
• Workshop: Fusion: Ultrasound and Fluoroscopy for Abdominal and Pelvic Blocks ASRA's 17th Annual Pain Medicine Meeting San Antonio, Texas November 15-17, 2018
• Workshop: ASRA -ASA Pain Medicine and MSK Ultrasound Cadaver Course: Chicago, Il April 2019
• Workshop: C2/Occipital Nerve block: ultrasound (model scans) American Interventional Headache Society meeting Chicago, IL, May 2019
• Workshop: Stellate Ganglion; ultrasound (model scans) American Interventional Headache Society meeting Chicago, IL, May 2019
• Workshop: Ultrasound-guided paravertebral, intercostal, and lumbar spine blocks: Society for Pain Practice Management Interventional Pain Management Course. Chicago Il, Sep 2019
• Workshop: Ultrasound-guided brachial plexus and stellate ganglion blocks: Society for Pain Practice Management Interventional Pain Management Course. Chicago Il, Sep 2019
• Visiting Professor: Upper limb: Infraclavicular Block, Lower limb: Sciatic Block Lebanese University, Virtual, April 2021
• Speaker: Managing Orofacial Pain and Headache: Role of Ultrasound-Guided Injections. "13th Pan Arab Congress of Anesthesia, Intensive Care & Pain Management" Virtual meeting, May 2021.
• Speaker: Bedside Pain Procedures: Migraine and Cephalalgia Management with Ultrasound-Guided Craniofacial Blocks. Ultrasound Workshop. American Society of Anesthesiology Annual Meeting, San Diego CA. October 2021
• Workshop: Hands-On Ultrasound Workshop Ultrasound in Pain Medicine. Quadratus Lumborum & Paravetebral Blocks. ASRA 20th Annual Pain Medicine Meeting. San Francisco CA. November 2021
• Workshop Leader: ASRA-ASA Ultrasound-Guided Regional Anesthesia Education Portfolio Cadaver Course, Chicago, IL November 2021
Complete List of Published Work in My Bibliography Relevant to this study: https://www.ncbi.nlm.nih.gov/pubmed/?term=nader+Antoun+pain
D. Additional Information: Research Support and/or Scholastic Performance
Research Support
SPR Therapeutics 2017-2020
A prospective, randomized, double-blind, placebo-controlled, multicenter study of the SPRINT peripheral nerve stimulation for post-traumatic phantom limb pain
Goal: A multicenter, randomized, double-blinded, placebo-controlled, partial-crossover study conducted to collect data on the safety and effectiveness of percutaneous PNS for chronic neuropathic pain in amputees. The primary hypothesis was that percutaneous PNS provides clinically significant pain relief in a statistically significantly greater proportion of subjects than the placebo control group.
Role: Northwestern Site PI
Funding: Department of Defense (CDMRP/PRORP W81XWH-12-2-0132) and SPR Therapeutics
"REGAIN Trial" 2016-2021
A Randomized Controlled Trial of Regional Versus General Anesthesia for Promoting Independence after Hip Fracture
Goal: Evaluate outcomes of common anaesthesia techniques for hip fracture surgery, an event that occurs over 1.6 million times each year worldwide, through an international, multicentre, randomised trial.
Role: Northwestern Site PI
Funding: Patient-Centered Outcomes Research Institute Prime Award, PCS-1406-18876 (PI:Neuman)
