.png "Michael Brenner, MD photo")
Brigham and Women's Hospital, Harvard Medical School
Newton, MA, United States
Michael B Brenner MD is the E.F. Brigham Professor of Medicine, Harvard Medical School; Director of the Human Immunology Center and the Single Cell Genomics Core at Brigham and Women’s Hospital, Boston. He is co-chair of the NIH RA/SLE AMP consortium. He is a member of the National Academy of Sciences, USA, and has received the Lee C. Howley Prize (Arthritis Foundation), Distinguished Basic Investigator Award (ACR) and the Carol-Nachman Prize in Rheumatology.
Brenner’s laboratory performs high dimensional immunophenotyping, single cell transcriptomic analyses and functional studies to deconstruct human autoimmune disorders. His laboratory 1) identified fibroblast subsets and activation mechanisms that mediate joint pathology in inflammatory arthritis, 2) defined the role of mesenchymal cadherins in fibroblast pathology and 3) peripheral helper T (Tph) cells that are pathologically expanded in rheumatoid arthritis and drive antibody production. In basic science studies, he 1) discovered gamma delta T cells, 2) defined the CD1 antigen presentation system by which lipid antigens are recognized by T cell receptors, 3) characterized the functions of CD1 restricted T cells and 4) identified regulatory pathways to control inflammation and drive thermogenesis in adipose tissue, 5) identified the role of CD103 (alphaEbeta7 integrin) in mucosal T cell homing.
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Monday, November 14, 2022
3:00 PM – 4:00 PM Eastern Time
