Dr Balmis Alicante General University Hospital-ISABIAL Alicante, Spain
Nalia Domínguez-Lirón1, Eugenio De Miguel2, Agustín Martínez-Sanchis3, Diana Peiteado2, Blanca Garcia-Magallon4, Esther Vicente-Rabaneda5, Enrique Calvo6, Basilio Rodríguez7, Alejandro Prada8, Boris Anthony Blanco Cáceres9, José Antonio Bernal10, Francisca Sivera11, Santos Castañeda5, Sonia Mínguez7, Laura Barrio8, Mónica Vázquez-Díaz9, José Miguel Senabre12, Cristina Bohorquez13 and Mariano Andrès3, 1Miguel Hernández University, Alicante, Spain, 2Hospital Universitario La Paz, Madrid, Spain, 3Dr Balmis Alicante General University Hospital-ISABIAL, Alicante, Spain, 4Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain, 5Division of Rheumatology, Hospital Universitario de La Princesa, IIS-Princesa, Madrid, Spain, 6Hospital Universitario Infanta Leonor, Madrid, Spain, 7Althaia Xarxa Assistencial Universitaria De Manresa, Manresa, Spain, 8Hospital Universitario de Torrejon, Madrid, Spain, 9Hospital Universitario Ramón y Cajal, Madrid, Spain, 10Hospital Marina Baixa (Villajoyosa), Alicante, Spain, 11Hospital Universitario de Elda, San Vicente del Raspeig, Spain, 12Hospital Marina Baixa, Villajoyosa, Spain, 13University Hospital Príncipe de Asturias, Immune System Diseases-Rheumatology Service, Alcalá de Henares, Madrid, Spain
Background/Purpose: The applicability of the preliminary remission criteria for gout [PMID 26414176] in clinical practice is unknown. This study evaluates the sonographic prevalence of monosodium urate (MSU) deposition and associated inflammation in patients with gout in remission.
Methods: Observational cross-sectional multicenter study. Patients with gout (ACR/EULAR classification criteria +/- MSU crystal-proven) who met preliminary remission criteria were consecutively recruited at eleven Spanish rheumatology units. We determined the prevalence (with 95% confidence interval -CI) of sonographic signs of MSU crystal deposits (tophi, aggregates and double contour sign) and inflammation by power Doppler [PD] signal (graded as 0-3, positive if ≥1). We followed a sonographic assessment that scanned bilaterally 1st metatarsophalangeal and 2nd metacarpophalangeal joints, knees, talar cartilages and patellar and Achilles tendons. Associations between deposits and PD signal and clinical and laboratory variables were also analyzed.
Results: We report our initial 71 participants, mean aged 66 years (SD 9.8) and 93.0% males. Mean gout duration was 14.7 years (SD 12.2), the disease was tophaceous at baseline in 15.5%, and mean serum urate (SU) level in the preceding year was 4.7 mg/dl (SD 0.8). MSU deposits were detected in at least one scanned site in 88.7% of participants (95%CI 79.3-94.2%), with a median of 3 locations with deposits (range 0-9). Articular deposits (81.7%) were more common than tendinous deposits (45.1%), and aggregates were the most frequent sonographic finding (76.1%) [Figure 1]. A positive PD signal was present in 32.4% of participants (95%CI 22.7-44.0%), mainly at joints (29.6%). Prevalent deposits and positive PD signal were found associated both at joints (p=0.049) and tendons (p=0.015). Regarding secondary variables, sonographic deposits were associated with higher maximal SU levels registered at lab records (9.2 mg/dl, IQR 8.2-10.0 versus 7.9 mg/dL, IQR 7.8-8.7, p=0.030). Participants with positive PD signal showed higher SU urate levels in the preceding year (5.1 mg/dl, IQR 4.7-5.4, versus 4.8 mg/dl, IQR 4.1-5.2, p=0.057). No other associations were found.
Conclusion: Most patients with gout fulfilling remission criteria have sonographic MSU crystal deposits, and one third also show subclinical sonographic inflammation. These data suggest that achieving remission criteria should not be taken as the disease cure in gout management. Disclosures: N. Domínguez-Lirón, None; E. De Miguel, None; A. Martínez-Sanchis, None; D. Peiteado, None; B. Garcia-Magallon, None; E. Vicente-Rabaneda, None; E. Calvo, None; B. Rodríguez, None; A. Prada, None; B. Blanco Cáceres, None; J. Bernal, None; F. Sivera, None; S. Castañeda, Roche; S. Mínguez, None; L. Barrio, None; M. Vázquez-Díaz, None; J. Senabre, None; C. Bohorquez, None; M. Andrès, Menarini, Grunenthal.
